Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1937132..1937908 Replicon chromosome
Accession NZ_CP092825
Organism Staphylococcus aureus strain GY8

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MK796_RS09400 Protein ID WP_000031108.1
Coordinates 1937132..1937284 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag MK796_RS09405 Protein ID WP_001251218.1
Coordinates 1937309..1937908 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK796_RS09385 (1933207) 1933207..1934028 + 822 WP_000669384.1 RluA family pseudouridine synthase -
MK796_RS09390 (1934493) 1934493..1935878 - 1386 WP_000116233.1 class II fumarate hydratase -
MK796_RS09395 (1936074) 1936074..1936469 - 396 WP_057504578.1 hypothetical protein -
MK796_RS09400 (1937132) 1937132..1937284 - 153 WP_000031108.1 SAS053 family protein Toxin
MK796_RS09405 (1937309) 1937309..1937908 - 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
MK796_RS09410 (1938067) 1938067..1938537 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MK796_RS09415 (1938542) 1938542..1939669 - 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
MK796_RS09420 (1939820) 1939820..1940542 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MK796_RS09425 (1940535) 1940535..1941992 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T237208 WP_000031108.1 NZ_CP092825:c1937284-1937132 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T237208 NZ_LR792630:c85847-85560 [Klebsiella pneumoniae]
ATGACATATACCGTCAAATTCAGGGAAGATGCGCTAAAAGAATGGAACAAGCTAGATAAGACTATTCAGCAGCAGTTTGC
AAAGAAACTTAAAAAGTGCTGTGAAAACCCACACATTCCTTCAGCAAAACTACGTGGTATAAAGGATTGCTATAAAATAA
AACTGCGAGCATCTGGTTTTCGCCTCGTCTATCAGGTCATAGATAATCAACTTATAATTGCTATTGTGGCTGTAGGCAAA
CGGGAGCGCAGTGACGTTTATACACTGGCGAGTGAACGTATGAAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT237208 WP_001251218.1 NZ_CP092825:c1937908-1937309 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT237208 NZ_LR792630:c86095-85844 [Klebsiella pneumoniae]
ATGCCACATATCATTCTGAGTGACACGACTGCCAGCGTCAGTGAATTGAAAAAAAACCCGATGGCCACAGTCAGCGCAGG
TGACGGGTTCCCAGTAGCGATTCTTAACCGGAACCAGCCAGCTTTCTATTGCGTGCCTGCGGAACTCTACGAAAAGATGC
TTGATGCGCTGGATGATCAGGAACTCATTAAACTGGTTGCAGAACGCAGTAATCAACCGCTGTTTGATATGGACCTGGAG
AAGTACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References