Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TscAT/-
Location 899566..900098 Replicon chromosome
Accession NZ_CP092825
Organism Staphylococcus aureus strain GY8

Toxin (Protein)


Gene name TscT Uniprot ID Q93CD4
Locus tag MK796_RS04425 Protein ID WP_001103942.1
Coordinates 899778..900098 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MK796_RS04420 Protein ID WP_001058486.1
Coordinates 899566..899775 (+) Length 70 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK796_RS04375 (894584) 894584..895804 - 1221 WP_000266157.1 site-specific integrase -
MK796_RS04380 (895893) 895893..896621 - 729 WP_000733774.1 staphylococcal enterotoxin type K -
MK796_RS04385 (896645) 896645..897373 - 729 WP_001033316.1 staphylococcal enterotoxin type Q -
MK796_RS04390 (897444) 897444..897875 - 432 WP_001228759.1 hypothetical protein -
MK796_RS04395 (897892) 897892..898350 - 459 WP_000281657.1 ImmA/IrrE family metallo-endopeptidase -
MK796_RS04400 (898362) 898362..898694 - 333 WP_001260004.1 helix-turn-helix transcriptional regulator -
MK796_RS04405 (898887) 898887..899150 + 264 WP_000243850.1 helix-turn-helix transcriptional regulator -
MK796_RS04410 (899143) 899143..899415 + 273 WP_000091731.1 helix-turn-helix domain-containing protein -
MK796_RS04415 (899427) 899427..899573 + 147 WP_000784875.1 hypothetical protein -
MK796_RS04420 (899566) 899566..899775 + 210 WP_001058486.1 hypothetical protein Antitoxin
MK796_RS04425 (899778) 899778..900098 + 321 WP_001103942.1 DUF1474 family protein Toxin
MK796_RS04430 (900162) 900162..901031 + 870 WP_241043471.1 primase alpha helix C-terminal domain-containing protein -
MK796_RS04435 (901048) 901048..902517 + 1470 WP_241043472.1 virulence-associated E family protein -
MK796_RS04440 (902803) 902803..903165 + 363 WP_001039168.1 hypothetical protein -
MK796_RS04445 (903167) 903167..903451 + 285 WP_000998181.1 hypothetical protein -
MK796_RS04450 (903448) 903448..904089 + 642 WP_001019764.1 hypothetical protein -
MK796_RS04455 (904606) 904606..904947 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 876549..909899 33350


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-98)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 107 a.a.        Molecular weight: 12694.22 Da        Isoelectric Point: 4.7419

>T237207 WP_001103942.1 NZ_CP092825:899778-900098 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Download         Length: 321 bp

>T237207 NZ_LR792630:c69986-69570 [Klebsiella pneumoniae]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8252.31 Da        Isoelectric Point: 4.3718

>AT237207 WP_001058486.1 NZ_CP092825:899566-899775 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT237207 NZ_LR792630:c70213-69983 [Klebsiella pneumoniae]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q93CD4


Antitoxin

Source ID Structure

References