Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 881869..882346 | Replicon | chromosome |
| Accession | NZ_CP092825 | ||
| Organism | Staphylococcus aureus strain GY8 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | MK796_RS04280 | Protein ID | WP_000052076.1 |
| Coordinates | 881869..882057 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | MK796_RS04285 | Protein ID | WP_001059690.1 |
| Coordinates | 882086..882346 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MK796_RS04250 (877907) | 877907..878377 | + | 471 | WP_000824462.1 | hypothetical protein | - |
| MK796_RS04255 (878718) | 878718..879404 | + | 687 | WP_001823812.1 | thermonuclease family protein | - |
| MK796_RS04260 (879761) | 879761..879961 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| MK796_RS04265 (880460) | 880460..880678 | - | 219 | WP_000005888.1 | hypothetical protein | - |
| MK796_RS04270 (880740) | 880740..881024 | - | 285 | WP_001004397.1 | hypothetical protein | - |
| MK796_RS04275 (881112) | 881112..881681 | - | 570 | WP_001106657.1 | lipoprotein N-acylation protein LnsA | - |
| MK796_RS04280 (881869) | 881869..882057 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| MK796_RS04285 (882086) | 882086..882346 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| MK796_RS04290 (882687) | 882687..882890 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| MK796_RS04295 (882887) | 882887..883123 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| MK796_RS04300 (883348) | 883348..883929 | + | 582 | WP_001140697.1 | histidine phosphatase family protein | - |
| MK796_RS04305 (884002) | 884002..884619 | - | 618 | WP_000255554.1 | LysE/ArgO family amino acid transporter | - |
| MK796_RS04310 (884775) | 884775..885269 | - | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
| MK796_RS04315 (885668) | 885668..886090 | - | 423 | WP_000974455.1 | organic hydroperoxide resistance protein | - |
| MK796_RS04320 (886238) | 886238..886954 | + | 717 | WP_000150029.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | selk / selq / seb | 876549..909899 | 33350 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T237206 WP_000052076.1 NZ_CP092825:c882057-881869 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T237206 NZ_LR792629:c106287-105805 [Klebsiella pneumoniae]
ATGGGAATGAGGCCTCCGGAACCTCTTACCCCTGAACACAACATTGCTGAGTTTTGTTGTCAGGATCAGGTTCTTTCTGA
GTGGTTGAAGAAAAAGGCGCTGAAGAATCACAGAACGGGCATTTCAAGAGTTTTCGTCGTCTGTGCTGAAAACACGAATA
GGGTAATTGCGTACTACTGTTTGGCATCCGGAAGCGTGCACAGAAACACCGTACCTGGAGCATACCGTCGTAATGCACCA
GAGGCTTTACCGGTCATTGTTCTGGGAAGGCTTGCGGTTGACGCTGCCTGGGCAAGAAAAGGGCTAGGAGCTGCGCTGCT
TAAGGATGCGATATACCGAACAGAACATATTGCAATACAGGTTGGTGTTAGGGCGCTTCTTGTTCACGCCTTAAATGATG
AAGTTAGGGAATTTTACACAAAGTTTGGATTCGAGCCCTCCATTGCCAATGCGCTGACATTATTATTTCCGATCAAAACA
TGA
ATGGGAATGAGGCCTCCGGAACCTCTTACCCCTGAACACAACATTGCTGAGTTTTGTTGTCAGGATCAGGTTCTTTCTGA
GTGGTTGAAGAAAAAGGCGCTGAAGAATCACAGAACGGGCATTTCAAGAGTTTTCGTCGTCTGTGCTGAAAACACGAATA
GGGTAATTGCGTACTACTGTTTGGCATCCGGAAGCGTGCACAGAAACACCGTACCTGGAGCATACCGTCGTAATGCACCA
GAGGCTTTACCGGTCATTGTTCTGGGAAGGCTTGCGGTTGACGCTGCCTGGGCAAGAAAAGGGCTAGGAGCTGCGCTGCT
TAAGGATGCGATATACCGAACAGAACATATTGCAATACAGGTTGGTGTTAGGGCGCTTCTTGTTCACGCCTTAAATGATG
AAGTTAGGGAATTTTACACAAAGTTTGGATTCGAGCCCTCCATTGCCAATGCGCTGACATTATTATTTCCGATCAAAACA
TGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT237206 WP_001059690.1 NZ_CP092825:c882346-882086 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT237206 NZ_LR792629:c106556-106278 [Klebsiella pneumoniae]
ATGAAACCAGACATTCGTGAGGCTCCGATAAACATCCGGGCGAAAACATCTCAACGCGATCTTATCGACATGGCCGCAAA
TCTTGTATCTAAATCACGTACTGATTTTATGCTGGAAGTGGCCTGCCGCGAAGCGCAGGACATCTTGTTAGATCAGCGCT
TGTTTCTGCTGGATGATAATCAGTTTAACGCGTTTGTCGAAGAGCTTGACGCCCCTATGACCCCAGAGCGTCAGGCGCGT
ATTGATAACCTGATGAGCCGCAAATCGCCATGGGAATGA
ATGAAACCAGACATTCGTGAGGCTCCGATAAACATCCGGGCGAAAACATCTCAACGCGATCTTATCGACATGGCCGCAAA
TCTTGTATCTAAATCACGTACTGATTTTATGCTGGAAGTGGCCTGCCGCGAAGCGCAGGACATCTTGTTAGATCAGCGCT
TGTTTCTGCTGGATGATAATCAGTTTAACGCGTTTGTCGAAGAGCTTGACGCCCCTATGACCCCAGAGCGTCAGGCGCGT
ATTGATAACCTGATGAGCCGCAAATCGCCATGGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |