Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2734761..2736349 Replicon chromosome
Accession NZ_CP092793
Organism Klebsiella pneumoniae strain XH1507

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag ML258_RS13560 Protein ID WP_004199851.1
Coordinates 2734761..2736083 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag ML258_RS13565 Protein ID WP_002904790.1
Coordinates 2736083..2736349 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ML258_RS13545 (ML258_13545) 2729826..2732327 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
ML258_RS13550 (ML258_13550) 2732315..2733319 + 1005 WP_004199852.1 fimbrial protein -
ML258_RS13555 (ML258_13555) 2733452..2734744 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
ML258_RS13560 (ML258_13560) 2734761..2736083 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
ML258_RS13565 (ML258_13565) 2736083..2736349 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ML258_RS13570 (ML258_13570) 2736615..2736941 - 327 WP_002904788.1 hydroxyisourate hydrolase -
ML258_RS13575 (ML258_13575) 2736938..2737438 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
ML258_RS13580 (ML258_13580) 2737416..2738795 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
ML258_RS13585 (ML258_13585) 2739141..2740295 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
ML258_RS13590 (ML258_13590) 2740276..2741199 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T237184 WP_004199851.1 NZ_CP092793:c2736083-2734761 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T237184 NZ_LR782232:2295403-2295506 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT237184 WP_002904790.1 NZ_CP092793:c2736349-2736083 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT237184 NZ_LR782232:c2295544-2295273 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References