Detailed information of TA system TA237169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsxAB/MqsA(antitoxin)
• Location: 25786..26272
• Replicon: plasmid pXH1508-4
• Accession: NZ_CP092790
• Organism: Klebsiella pneumoniae strain XH1508

Toxin (Protein)

• Gene name: TsxA
• Uniprot ID: -
• Locus tag: ML259_RS29660
• Protein ID: WP_212656694.1
• Coordinates: 25786..26052 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: TsxB
• Uniprot ID: -
• Locus tag: ML259_RS29665
• Protein ID: WP_073546961.1
• Coordinates: 26042..26272 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ML259_RS29630 (ML259_29630)	21464..21703	-	240	WP_113355614.1	hypothetical protein	-
ML259_RS29635 (ML259_29635)	21774..21989	-	216	WP_212656689.1	hypothetical protein	-
ML259_RS29640 (ML259_29640)	22056..22466	-	411	WP_212656690.1	hypothetical protein	-
ML259_RS29645 (ML259_29645)	22476..23453	-	978	WP_212656691.1	replication initiator protein A	-
ML259_RS29650 (ML259_29650)	24435..24959	+	525	WP_212656692.1	J domain-containing protein	-
ML259_RS29655 (ML259_29655)	25213..25764	+	552	WP_212656693.1	hypothetical protein	-
ML259_RS29660 (ML259_29660)	25786..26052	+	267	WP_212656694.1	hypothetical protein	Toxin
ML259_RS29665 (ML259_29665)	26042..26272	+	231	WP_073546961.1	hypothetical protein	Antitoxin
ML259_RS29670 (ML259_29670)	26645..26857	+	213	WP_073546991.1	hypothetical protein	-
ML259_RS29675 (ML259_29675)	26904..27047	+	144	WP_212656695.1	hypothetical protein	-
ML259_RS29870	27123..27257	+	135	WP_259493503.1	hypothetical protein	-
ML259_RS29680 (ML259_29680)	27377..27673	+	297	WP_012368903.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ML259_RS29685 (ML259_29685)	27675..27959	+	285	WP_012368902.1	putative addiction module antidote protein	-
ML259_RS29690 (ML259_29690)	28667..29215	+	549	WP_212656696.1	TraY domain protein	-
ML259_RS29695 (ML259_29695)	29223..30383	+	1161	WP_212656697.1	MobP1 family relaxase	-
ML259_RS29700 (ML259_29700)	30393..30749	+	357	WP_212656698.1	DNA distortion polypeptide 3	-
ML259_RS29705 (ML259_29705)	30726..31250	-	525	WP_212656699.1	restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..34012	34012

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (5-35)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10213.78 Da
• Isoelectric Point: 10.1699

>T237169 WP_212656694.1 NZ_CP092790:25786-26052 [Klebsiella pneumoniae]
MKTIRKNKGDVTYYLSRDNNDSYRLIKKIKARATHLVKDGHKTTKITLSDLLLTHDQLYNLDYSLNGLRADDKITIELLI
GEFFKNGK

Nucleotide

• Length: 267 bp

>T237169 NZ_LR778301:24948-25271 [Denitratisoma oestradiolicum]
ATGGTCTTTGTGGAACTCCCGATCTTCGTCCGCTGTGCAGCCGAACTGTTCTCGGATGAGGATATGGCCGAGTTGCAGAA
CACCTTGCTGGAAAACCCTGCCGCCGGTGACTTGATCCCCGGTGGTCGGGGTTTGCGCAAGCTGCGTGTTCCGCTGCCTG
GTCGAGGCAAGCGTGGCGGTGCCCGGGTGATCTACTACCACTGGGTCAGCAAGGCGCAGTGCTATCTGATCTACGCCTAC
GCGAAGAATGTCAGTGCGAACCTGACGCCGGATCAGCTGCGGCGGTTGGCTGAAGTGATGCAAGCGGAGATACGAGATGA
ATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8772.96 Da
• Isoelectric Point: 8.5162

>AT237169 WP_073546961.1 NZ_CP092790:26042-26272 [Klebsiella pneumoniae]
MENNAKNIKALRLKTGLTQKEMAERYGVGIRTWQKKEEDGTQSSQKLSNFDFEYLLLLAGEHPDFVLEKRNKEVAS

Nucleotide

• Length: 231 bp

>AT237169 NZ_LR778301:25264-25554 [Denitratisoma oestradiolicum]
ATGAATGACAAACAGTTCGATGAGTTGCTGAGCAGCGTACGTGACATGGGCCGCCATATGCGTGGTGAGGCCGTGGCCGG
TGTGCGTGTGCAGGAGTTTCCCGAGCCCGATGTCAAGGCGATCCGTGAGCGCACGGGGCTTTCGCAGAGTCGGTTTGCCT
ACCTGATTGGCGTCAAGCCCAAGACACTTCAGAACTGGGAGCAGCGCCGAGTGCGTCCTGCCGGGCCGGCTCGCGCCTTG
CTCAAGATCGTCGAAGCCAACCCCGACGCGCTATCGGCCATTCACGCGTGA