Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 84093..85003 Replicon plasmid pXH1508-1
Accession NZ_CP092787
Organism Klebsiella pneumoniae strain XH1508

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag ML259_RS27515 Protein ID WP_004026354.1
Coordinates 84093..84563 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag ML259_RS27520 Protein ID WP_004026357.1
Coordinates 84560..85003 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ML259_RS27475 (ML259_27475) 79409..79723 + 315 WP_011251273.1 hypothetical protein -
ML259_RS27480 (ML259_27480) 79732..80226 + 495 WP_011251274.1 hypothetical protein -
ML259_RS27485 (ML259_27485) 80232..80672 + 441 WP_011251275.1 hypothetical protein -
ML259_RS27490 (ML259_27490) 81097..82053 - 957 WP_011251280.1 DsbA family protein -
ML259_RS27495 (ML259_27495) 82113..82454 - 342 WP_011251281.1 hypothetical protein -
ML259_RS27500 (ML259_27500) 82468..82779 - 312 WP_011251282.1 hypothetical protein -
ML259_RS27505 (ML259_27505) 82796..83245 - 450 WP_011251283.1 thioredoxin fold domain-containing protein -
ML259_RS27515 (ML259_27515) 84093..84563 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
ML259_RS27520 (ML259_27520) 84560..85003 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
ML259_RS27525 (ML259_27525) 85104..85607 - 504 Protein_97 DUF4113 domain-containing protein -
ML259_RS27530 (ML259_27530) 85813..86793 - 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
ML259_RS27535 (ML259_27535) 86859..88166 + 1308 Protein_99 FepA family TonB-dependent siderophore receptor -
ML259_RS27540 (ML259_27540) 88228..88449 + 222 WP_004213615.1 hypothetical protein -
ML259_RS27545 (ML259_27545) 88592..89494 - 903 WP_004213613.1 DMT family inner membrane transporter PEG344 -
ML259_RS27550 (ML259_27550) 89567..89968 - 402 WP_214588034.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..198615 198615
- inside IScluster/Tn - iroN / rmpA 77812..97788 19976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T237163 WP_004026354.1 NZ_CP092787:c84563-84093 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T237163 NZ_LR778153:3806474-3807016 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT237163 WP_004026357.1 NZ_CP092787:c85003-84560 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT237163 NZ_LR778153:3806179-3806490 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References