Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 880092..880746 Replicon chromosome
Accession NZ_CP092786
Organism Klebsiella pneumoniae strain XH1508

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag ML259_RS04440 Protein ID WP_004144731.1
Coordinates 880339..880746 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag ML259_RS04435 Protein ID WP_002916312.1
Coordinates 880092..880358 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ML259_RS04410 (ML259_04410) 875248..876681 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
ML259_RS04415 (ML259_04415) 876800..877528 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
ML259_RS04420 (ML259_04420) 877578..877889 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
ML259_RS04425 (ML259_04425) 878053..878712 + 660 WP_002916317.1 hemolysin III family protein -
ML259_RS04430 (ML259_04430) 878863..879846 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
ML259_RS04435 (ML259_04435) 880092..880358 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
ML259_RS04440 (ML259_04440) 880339..880746 + 408 WP_004144731.1 protein YgfX Toxin
ML259_RS04445 (ML259_04445) 880753..881274 - 522 WP_002916308.1 flavodoxin FldB -
ML259_RS04450 (ML259_04450) 881375..882271 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
ML259_RS04455 (ML259_04455) 882294..883007 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ML259_RS04460 (ML259_04460) 883013..884746 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T237146 WP_004144731.1 NZ_CP092786:880339-880746 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T237146 NZ_LR778152:4556604-4556915 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT237146 WP_002916312.1 NZ_CP092786:880092-880358 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237146 NZ_LR778152:4556916-4557332 [Escherichia coli]
CTGACTAATGCTGAACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTCAGA
AGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGATACTAATCCACTTATCGACTTTCTGA
CGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTTGGC
GTGGCGTTACTTCGTACGCTGATTGATCAACATAATCTGACCTATGCAGATTTGAAGAACGAAATCGGCTCTAAATCCCT
GGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTAAGC
CGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References