Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2879826..2880445 Replicon chromosome
Accession NZ_CP092780
Organism Massilia sp. MB5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MJ904_RS13055 Protein ID WP_082219507.1
Coordinates 2879826..2880008 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0K1JZ25
Locus tag MJ904_RS13060 Protein ID WP_050409107.1
Coordinates 2880020..2880445 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ904_RS13030 (MJ904_13030) 2874927..2875535 - 609 WP_050409111.1 YqhA family protein -
MJ904_RS13035 (MJ904_13035) 2875790..2877787 + 1998 WP_050409110.1 acetate--CoA ligase -
MJ904_RS13045 (MJ904_13045) 2878611..2878796 + 186 WP_050409109.1 TonB family protein -
MJ904_RS13050 (MJ904_13050) 2879306..2879506 - 201 WP_082219508.1 DUF3079 domain-containing protein -
MJ904_RS13055 (MJ904_13055) 2879826..2880008 + 183 WP_082219507.1 type II toxin-antitoxin system HicA family toxin Toxin
MJ904_RS13060 (MJ904_13060) 2880020..2880445 + 426 WP_050409107.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MJ904_RS13065 (MJ904_13065) 2880488..2884471 - 3984 WP_240737647.1 FAD-dependent oxidoreductase -
MJ904_RS13070 (MJ904_13070) 2884658..2885437 - 780 WP_240737648.1 trypsin-like serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6882.04 Da        Isoelectric Point: 11.9537

>T237131 WP_082219507.1 NZ_CP092780:2879826-2880008 [Massilia sp. MB5]
MNSKTLIDMLKADGWQLVRIRGSHHHFRHPGKNGLITVPHPKKDLPAGTWRRILHDAGLR

Download         Length: 183 bp

>T237131 NZ_LR778152:1349478-1349585 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15632.76 Da        Isoelectric Point: 4.6257

>AT237131 WP_050409107.1 NZ_CP092780:2880020-2880445 [Massilia sp. MB5]
MDLPVIIFKDEGSVYGVSVPDISGCHSWGDTIGDALRNVKEAIASHIETLLELGENIEVTPSDIECLRERPEYEGAIWAL
VNVDLSKLDSKPERINISLPRFVLSKIDKYADERHETRSGLLARAAVKLINDETALKTSKT

Download         Length: 426 bp

>AT237131 NZ_LR778152:c1349425-1349364 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0K1JZ25

References