Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2679853..2681441 Replicon chromosome
Accession NZ_CP092765
Organism Klebsiella pneumoniae strain bat15

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag MKZ43_RS13330 Protein ID WP_002904792.1
Coordinates 2679853..2681175 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag MKZ43_RS13335 Protein ID WP_002904790.1
Coordinates 2681175..2681441 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ43_RS13315 (MKZ43_13315) 2674909..2677410 + 2502 WP_004151634.1 fimbria/pilus outer membrane usher protein -
MKZ43_RS13320 (MKZ43_13320) 2677398..2678402 + 1005 WP_002904798.1 fimbrial protein -
MKZ43_RS13325 (MKZ43_13325) 2678544..2679836 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
MKZ43_RS13330 (MKZ43_13330) 2679853..2681175 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
MKZ43_RS13335 (MKZ43_13335) 2681175..2681441 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MKZ43_RS13340 (MKZ43_13340) 2681707..2682033 - 327 WP_002904788.1 hydroxyisourate hydrolase -
MKZ43_RS13345 (MKZ43_13345) 2682030..2682530 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
MKZ43_RS13350 (MKZ43_13350) 2682508..2683887 - 1380 WP_002904785.1 nucleobase:cation symporter-2 family protein -
MKZ43_RS13355 (MKZ43_13355) 2684233..2685387 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
MKZ43_RS13360 (MKZ43_13360) 2685368..2686291 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T237118 WP_002904792.1 NZ_CP092765:c2681175-2679853 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T237118 NZ_LR778151:c2406475-2406077 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT237118 WP_002904790.1 NZ_CP092765:c2681441-2681175 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT237118 NZ_LR778151:c2406702-2406475 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References