Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874103..874760 Replicon chromosome
Accession NZ_CP092765
Organism Klebsiella pneumoniae strain bat15

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MKZ43_RS04405 Protein ID WP_002916310.1
Coordinates 874350..874760 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MKZ43_RS04400 Protein ID WP_002916312.1
Coordinates 874103..874369 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ43_RS04375 (MKZ43_04375) 869259..870692 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MKZ43_RS04380 (MKZ43_04380) 870811..871539 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MKZ43_RS04385 (MKZ43_04385) 871589..871900 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MKZ43_RS04390 (MKZ43_04390) 872064..872723 + 660 WP_002916317.1 hemolysin III family protein -
MKZ43_RS04395 (MKZ43_04395) 872874..873857 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MKZ43_RS04400 (MKZ43_04400) 874103..874369 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MKZ43_RS04405 (MKZ43_04405) 874350..874760 + 411 WP_002916310.1 protein YgfX Toxin
MKZ43_RS04410 (MKZ43_04410) 874767..875288 - 522 WP_002916308.1 flavodoxin FldB -
MKZ43_RS04415 (MKZ43_04415) 875389..876285 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MKZ43_RS04420 (MKZ43_04420) 876308..877021 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MKZ43_RS04425 (MKZ43_04425) 877027..878760 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T237109 WP_002916310.1 NZ_CP092765:874350-874760 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T237109 NZ_LR778151:c1059571-1059464 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT237109 WP_002916312.1 NZ_CP092765:874103-874369 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237109 NZ_LR778151:1059619-1059685 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References