Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874217..874874 Replicon chromosome
Accession NZ_CP092759
Organism Klebsiella pneumoniae strain bat16

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MKZ45_RS04410 Protein ID WP_002916310.1
Coordinates 874464..874874 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MKZ45_RS04405 Protein ID WP_002916312.1
Coordinates 874217..874483 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ45_RS04380 (MKZ45_04380) 869373..870806 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MKZ45_RS04385 (MKZ45_04385) 870925..871653 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MKZ45_RS04390 (MKZ45_04390) 871703..872014 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MKZ45_RS04395 (MKZ45_04395) 872178..872837 + 660 WP_002916317.1 hemolysin III family protein -
MKZ45_RS04400 (MKZ45_04400) 872988..873971 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MKZ45_RS04405 (MKZ45_04405) 874217..874483 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MKZ45_RS04410 (MKZ45_04410) 874464..874874 + 411 WP_002916310.1 protein YgfX Toxin
MKZ45_RS04415 (MKZ45_04415) 874881..875402 - 522 WP_002916308.1 flavodoxin FldB -
MKZ45_RS04420 (MKZ45_04420) 875503..876399 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MKZ45_RS04425 (MKZ45_04425) 876422..877135 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MKZ45_RS04430 (MKZ45_04430) 877141..878874 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T237090 WP_002916310.1 NZ_CP092759:874464-874874 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T237090 NZ_LR778150:c675968-675504 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT237090 WP_002916312.1 NZ_CP092759:874217-874483 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237090 NZ_LR778150:c676303-675968 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References