Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 89389..90125 Replicon plasmid unnamed1
Accession NZ_CP092754
Organism Klebsiella pneumoniae strain bat17

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag MKZ44_RS26855 Protein ID WP_003026803.1
Coordinates 89643..90125 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag MKZ44_RS26850 Protein ID WP_003026799.1
Coordinates 89389..89655 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ44_RS26805 (MKZ44_26795) 85453..85814 - 362 Protein_93 arsenite efflux transporter metallochaperone ArsD -
MKZ44_RS26810 (MKZ44_26800) 85864..86214 - 351 WP_004152101.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
MKZ44_RS26815 (MKZ44_26805) 86572..86841 + 270 WP_004152102.1 hypothetical protein -
MKZ44_RS26820 (MKZ44_26810) 86829..87404 + 576 WP_004152103.1 hypothetical protein -
MKZ44_RS26825 (MKZ44_26815) 87435..87929 + 495 Protein_97 DNA-binding protein -
MKZ44_RS26830 (MKZ44_26820) 87973..88341 + 369 WP_004152105.1 hypothetical protein -
MKZ44_RS26835 (MKZ44_26825) 88375..88577 + 203 Protein_99 hemolysin expression modulator Hha -
MKZ44_RS26840 (MKZ44_26830) 88626..88883 + 258 WP_004152107.1 hypothetical protein -
MKZ44_RS26845 (MKZ44_26835) 88959..89213 + 255 WP_004152108.1 hypothetical protein -
MKZ44_RS26850 (MKZ44_26840) 89389..89655 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
MKZ44_RS26855 (MKZ44_26845) 89643..90125 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
MKZ44_RS26860 (MKZ44_26850) 90337..91682 + 1346 Protein_104 ISNCY family transposase -
MKZ44_RS29170 91843..91974 + 132 WP_004218042.1 hypothetical protein -
MKZ44_RS26865 (MKZ44_26855) 92183..93347 - 1165 Protein_106 IS3 family transposase -
MKZ44_RS26870 (MKZ44_26860) 93524..94485 - 962 Protein_107 zinc metalloprotease HtpX -
MKZ44_RS26875 (MKZ44_26865) 94472..94960 - 489 WP_004152114.1 phosphate-starvation-inducible PsiE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-Ia / mph(A) / sul1 / qacE / aadA2 / dfrA12 / catA1 / blaKPC-3 / blaOXA-9 / blaTEM-1A - 1..228673 228673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T237085 WP_003026803.1 NZ_CP092754:89643-90125 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T237085 NZ_LR778149:3961326-3961733 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT237085 WP_003026799.1 NZ_CP092754:89389-89655 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT237085 NZ_LR778149:3961079-3961345 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References