Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4773566..4774082 Replicon chromosome
Accession NZ_CP092753
Organism Klebsiella pneumoniae strain bat17

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MKZ44_RS23655 Protein ID WP_002886902.1
Coordinates 4773566..4773850 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MKZ44_RS23660 Protein ID WP_002886901.1
Coordinates 4773840..4774082 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ44_RS23630 (MKZ44_23620) 4769050..4769313 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
MKZ44_RS23635 (MKZ44_23625) 4769443..4769616 + 174 WP_002886906.1 hypothetical protein -
MKZ44_RS23640 (MKZ44_23630) 4769619..4770362 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MKZ44_RS23645 (MKZ44_23635) 4770719..4772857 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MKZ44_RS23650 (MKZ44_23640) 4773098..4773562 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MKZ44_RS23655 (MKZ44_23645) 4773566..4773850 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKZ44_RS23660 (MKZ44_23650) 4773840..4774082 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MKZ44_RS23665 (MKZ44_23655) 4774160..4776070 - 1911 WP_004152270.1 PRD domain-containing protein -
MKZ44_RS23670 (MKZ44_23660) 4776093..4777247 - 1155 WP_002886900.1 lactonase family protein -
MKZ44_RS23675 (MKZ44_23665) 4777313..4778053 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T237082 WP_002886902.1 NZ_CP092753:c4773850-4773566 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T237082 NZ_LR778149:c2892342-2892031 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT237082 WP_002886901.1 NZ_CP092753:c4774082-4773840 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT237082 NZ_LR778149:c2892030-2891740 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References