Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874226..874883 Replicon chromosome
Accession NZ_CP092753
Organism Klebsiella pneumoniae strain bat17

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MKZ44_RS04405 Protein ID WP_002916310.1
Coordinates 874473..874883 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MKZ44_RS04400 Protein ID WP_002916312.1
Coordinates 874226..874492 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ44_RS04375 (MKZ44_04375) 869382..870815 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MKZ44_RS04380 (MKZ44_04380) 870934..871662 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MKZ44_RS04385 (MKZ44_04385) 871712..872023 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MKZ44_RS04390 (MKZ44_04390) 872187..872846 + 660 WP_002916317.1 hemolysin III family protein -
MKZ44_RS04395 (MKZ44_04395) 872997..873980 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MKZ44_RS04400 (MKZ44_04400) 874226..874492 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MKZ44_RS04405 (MKZ44_04405) 874473..874883 + 411 WP_002916310.1 protein YgfX Toxin
MKZ44_RS04410 (MKZ44_04410) 874890..875411 - 522 WP_002916308.1 flavodoxin FldB -
MKZ44_RS04415 (MKZ44_04415) 875512..876408 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MKZ44_RS04420 (MKZ44_04420) 876431..877144 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MKZ44_RS04425 (MKZ44_04425) 877150..878883 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T237070 WP_002916310.1 NZ_CP092753:874473-874883 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T237070 NZ_LR778148:c4595188-4594790 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT237070 WP_002916312.1 NZ_CP092753:874226-874492 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237070 NZ_LR778148:c4595415-4595188 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References