23707

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 351428..351975 Replicon chromosome II
Accession NC_012580
Organism Vibrio cholerae M66-2

Toxin (Protein)


Gene name relE Uniprot ID C3LV30
Locus tag VCM66_RS15000 Protein ID WP_000229318.1
Coordinates 351673..351975 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag VCM66_RS14995 Protein ID WP_000861987.1
Coordinates 351428..351685 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCM66_RS18770 346571..346684 + 114 WP_001900214.1 hypothetical protein -
VCM66_RS14945 346633..346914 + 282 WP_001894429.1 DUF1289 domain-containing protein -
VCM66_RS14955 347172..347708 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
VCM66_RS14960 347845..348360 + 516 WP_001201509.1 lipocalin family protein -
VCM66_RS14965 348510..349007 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
VCM66_RS14970 349004..349276 - 273 WP_000246253.1 DUF1778 domain-containing protein -
VCM66_RS18790 349669..349794 + 126 WP_001900195.1 DUF645 family protein -
VCM66_RS19320 349810..349848 + 39 WP_106019118.1 hypothetical protein -
VCM66_RS14980 350044..350490 + 447 WP_000006157.1 hypothetical protein -
VCM66_RS14985 350638..350907 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
VCM66_RS14990 350900..351178 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
VCM66_RS14995 351428..351685 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCM66_RS15000 351673..351975 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCM66_RS18795 352264..352488 + 225 WP_001894423.1 DUF3709 domain-containing protein -
VCM66_RS18800 352932..353051 + 120 WP_071919600.1 DUF645 family protein -
VCM66_RS19335 353055..353108 + 54 Protein_329 DUF645 family protein -
VCM66_RS15010 353710..354714 + 1005 WP_000964931.1 LD-carboxypeptidase -
VCM66_RS15020 355489..355669 + 181 Protein_331 DUF645 family protein -
VCM66_RS15025 355936..356223 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
VCM66_RS15030 356234..356551 + 318 WP_001232701.1 HigA family addiction module antidote protein -
VCM66_RS19550 356548..356658 + 111 WP_134814058.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 305869..409778 103909
- inside Integron - - 310949..409402 98453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11751.69 Da        Isoelectric Point: 5.1972

>T23707 WP_000229318.1 NC_012580:351673-351975 [Vibrio cholerae M66-2]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T23707 NC_012580:351673-351975 [Vibrio cholerae M66-2]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCATCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT23707 WP_000861987.1 NC_012580:351428-351685 [Vibrio cholerae M66-2]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT23707 NC_012580:351428-351685 [Vibrio cholerae M66-2]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C3LV30

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References