Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 48098..48663 Replicon plasmid pLiSL39
Accession NZ_CP092744
Organism Leptospira interrogans strain FMAS_PD1

Toxin (Protein)


Gene name mazF Uniprot ID A0A0F6H5X2
Locus tag FH585_RS20885 Protein ID WP_000648189.1
Coordinates 48098..48346 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0C5XAD8
Locus tag FH585_RS20890 Protein ID WP_000237066.1
Coordinates 48340..48663 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH585_RS20870 (FH585_20875) 44489..44965 + 477 WP_000691823.1 hypothetical protein -
FH585_RS20875 (FH585_20880) 45199..46137 - 939 WP_000852605.1 Rpn family recombination-promoting nuclease/putative transposase -
FH585_RS20880 (FH585_20885) 46409..46858 - 450 WP_240739037.1 leucine-rich repeat domain-containing protein -
FH585_RS20885 (FH585_20890) 48098..48346 + 249 WP_000648189.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
FH585_RS20890 (FH585_20895) 48340..48663 + 324 WP_000237066.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
FH585_RS20895 (FH585_20900) 48888..49100 + 213 WP_000447737.1 hypothetical protein -
FH585_RS20900 (FH585_20905) 49178..49570 + 393 WP_225741611.1 hypothetical protein -
FH585_RS20905 (FH585_20910) 49798..50113 + 316 Protein_54 chromosome partitioning protein ParB -
FH585_RS20910 (FH585_20915) 50529..51671 + 1143 WP_240739038.1 helix-turn-helix domain-containing protein -
FH585_RS20915 (FH585_20920) 52062..52526 - 465 WP_000207207.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..73333 73333


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(6-49)

Antitoxin

mRNA interferase PemK-like

(2-105)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9507.04 Da        Isoelectric Point: 5.1749

>T237061 WP_000648189.1 NZ_CP092744:48098-48346 [Leptospira interrogans]
MKASVVKIGNSKGIRIPKAVLEECHIEEEVDLLIDNNKLIIVPLKSKPREGWEKQFKTMSSNKDDKLFIPDSIDLLDKDW
EW

Download         Length: 249 bp

>T237061 NZ_LR778148:c3257619-3257512 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12168.59 Da        Isoelectric Point: 10.5161

>AT237061 WP_000237066.1 NZ_CP092744:48340-48663 [Leptospira interrogans]
MVISQYEVYLINLDPTVGHEIKKSRPCAIISPNEMNKTIGTIIIAPMTTKSRSYPTRVELTFQGKKGWIVLDQIRAVDKT
RLVKKLGKIDPKTVNKMKLVIKEMLVD

Download         Length: 324 bp

>AT237061 NZ_LR778148:3257667-3257733 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6H5X2

Antitoxin

Source ID Structure
AlphaFold DB A0A0C5XAD8

References