23706

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 350638..351178 Replicon chromosome II
Accession NC_012580
Organism Vibrio cholerae M66-2

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag VCM66_RS14985 Protein ID WP_000277238.1
Coordinates 350638..350907 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag VCM66_RS14990 Protein ID WP_001258569.1
Coordinates 350900..351178 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCM66_RS14935 345642..345884 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VCM66_RS14940 346128..346514 + 387 WP_001015867.1 NUDIX hydrolase -
VCM66_RS18770 346571..346684 + 114 WP_001900214.1 hypothetical protein -
VCM66_RS14945 346633..346914 + 282 WP_001894429.1 DUF1289 domain-containing protein -
VCM66_RS14955 347172..347708 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
VCM66_RS14960 347845..348360 + 516 WP_001201509.1 lipocalin family protein -
VCM66_RS14965 348510..349007 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
VCM66_RS14970 349004..349276 - 273 WP_000246253.1 DUF1778 domain-containing protein -
VCM66_RS18790 349669..349794 + 126 WP_001900195.1 DUF645 family protein -
VCM66_RS19320 349810..349848 + 39 WP_106019118.1 hypothetical protein -
VCM66_RS14980 350044..350490 + 447 WP_000006157.1 hypothetical protein -
VCM66_RS14985 350638..350907 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
VCM66_RS14990 350900..351178 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VCM66_RS14995 351428..351685 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VCM66_RS15000 351673..351975 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin -
VCM66_RS18795 352264..352488 + 225 WP_001894423.1 DUF3709 domain-containing protein -
VCM66_RS18800 352932..353051 + 120 WP_071919600.1 DUF645 family protein -
VCM66_RS19335 353055..353108 + 54 Protein_329 DUF645 family protein -
VCM66_RS15010 353710..354714 + 1005 WP_000964931.1 LD-carboxypeptidase -
VCM66_RS15020 355489..355669 + 181 Protein_331 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 305869..409778 103909
- inside Integron - - 310949..409402 98453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T23706 WP_000277238.1 NC_012580:c350907-350638 [Vibrio cholerae M66-2]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T23706 NC_012580:c350907-350638 [Vibrio cholerae M66-2]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT23706 WP_001258569.1 NC_012580:c351178-350900 [Vibrio cholerae M66-2]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT23706 NC_012580:c351178-350900 [Vibrio cholerae M66-2]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure
AlphaFold DB A0A151KTP9

References