Detailed information of TA system TA237056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 3219208..3219614
• Replicon: chromosome
• Accession: NZ_CP092739
• Organism: Leptospira interrogans strain FMAS_AW2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FH582_RS15970
• Protein ID: WP_240738011.1
• Coordinates: 3219429..3219614 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FH582_RS15965
• Protein ID: WP_240738010.1
• Coordinates: 3219208..3219411 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FH582_RS15960 (FH582_15955)	3218902..3219054	+	153	WP_240738009.1	hypothetical protein	-
FH582_RS15965 (FH582_15960)	3219208..3219411	-	204	WP_240738010.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FH582_RS15970 (FH582_15965)	3219429..3219614	-	186	WP_240738011.1	type II toxin-antitoxin system HicA family toxin	Toxin
FH582_RS15975 (FH582_15970)	3219678..3219956	-	279	WP_240738012.1	hypothetical protein	-
FH582_RS15980 (FH582_15975)	3219953..3220924	-	972	WP_240738013.1	chromosome partitioning protein ParB	-
FH582_RS15985 (FH582_15980)	3220954..3221733	-	780	WP_240738014.1	ParA family protein	-
FH582_RS15990 (FH582_15985)	3221861..3222898	-	1038	WP_240738015.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-63)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6732.91 Da
• Isoelectric Point: 10.8214

>T237056 WP_240738011.1 NZ_CP092739:c3219614-3219429 [Leptospira interrogans]
MKVKEIIKILEADGWYLVDQRGSHRQFKHGIKSGRVTVAGKASMDIPPGTLNSILKQSGLK

Nucleotide

• Length: 186 bp

>T237056 NZ_LR778148:c886000-885725 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7351.43 Da
• Isoelectric Point: 4.2412

>AT237056 WP_240738010.1 NZ_CP092739:c3219411-3219208 [Leptospira interrogans]
MEYPVIIEKSSTGYGAYVPDLPGCVSVGETEEEVTRLIKEAIEYHLEGMRRDGELIPAPSKVTLIAV

Nucleotide

• Length: 204 bp

>AT237056 NZ_LR778148:c885728-885369 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA