Detailed information of TA system TA237051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 834192..834865
• Replicon: chromosome
• Accession: NZ_CP092734
• Organism: Aristophania vespae strain DM15PD

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DM15PD_RS03910
• Protein ID: WP_236646461.1
• Coordinates: 834192..834584 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DM15PD_RS03915
• Protein ID: WP_236646462.1
• Coordinates: 834596..834865 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM15PD_RS03875 (DM15PD_07800)	830622..831248	+	627	WP_272916088.1	hypothetical protein	-
DM15PD_RS03880	831245..831568	+	324	WP_272916089.1	hypothetical protein	-
DM15PD_RS03885	831565..831888	+	324	WP_272916090.1	hypothetical protein	-
DM15PD_RS03890	831885..832208	+	324	WP_272916091.1	hypothetical protein	-
DM15PD_RS03895 (DM15PD_07810)	832205..832420	+	216	WP_160619109.1	hypothetical protein	-
DM15PD_RS03900 (DM15PD_07820)	832407..832649	+	243	WP_272916092.1	hypothetical protein	-
DM15PD_RS03905 (DM15PD_07830)	832651..833979	+	1329	WP_272916093.1	DUF935 family protein	-
DM15PD_RS03910 (DM15PD_07840)	834192..834584	-	393	WP_236646461.1	type II toxin-antitoxin system VapC family toxin	Toxin
DM15PD_RS03915 (DM15PD_07850)	834596..834865	-	270	WP_236646462.1	antitoxin	Antitoxin
DM15PD_RS03920 (DM15PD_07860)	835794..836351	-	558	WP_272916094.1	hypothetical protein	-
DM15PD_RS03925 (DM15PD_07870)	836675..837229	-	555	WP_272916095.1	hypothetical protein	-
DM15PD_RS03930 (DM15PD_07880)	837766..838338	-	573	WP_272916096.1	hypothetical protein	-
DM15PD_RS03935 (DM15PD_07890)	838778..839332	-	555	WP_272916097.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	816756..858183	41427

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-112)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 13832.91 Da
• Isoelectric Point: 5.4652

>T237051 WP_236646461.1 NZ_CP092734:c834584-834192 [Aristophania vespae]
MLDTNIVSELAQNPHGPVSHKIAEIGDDAICVSIITAAELHYGCAKKGSAKLTHQIEAILNSVKIMALDIPVDNQYGTIR
TQLEASGHVISPHNLLVATQASALGAIVVTSNIEEFGKLEGLKLENWLAL

Nucleotide

• Length: 393 bp

>T237051 NZ_LR778147:c5031797-5031507 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9866.35 Da
• Isoelectric Point: 5.6566

>AT237051 WP_236646462.1 NZ_CP092734:c834865-834596 [Aristophania vespae]
VPYSSLIKTSTPREARLFRNNKSQAVRIPVDFELPGKSVLIHKDGDCLIIEPLAHKGLSAALANLQPLLPEDYFPEINTT
SQPLSEIEL

Nucleotide

• Length: 270 bp

>AT237051 NZ_LR778147:c5032029-5031787 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA