Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1199830..1200431 Replicon chromosome
Accession NZ_CP092733
Organism Comamonas thiooxydans strain CHJ01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MJ608_RS05530 Protein ID WP_256630520.1
Coordinates 1199830..1200216 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MJ608_RS05535 Protein ID WP_256630521.1
Coordinates 1200216..1200431 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ608_RS05520 (MJ608_05505) 1197584..1198894 - 1311 WP_256630518.1 DNA polymerase Y family protein -
MJ608_RS05525 (MJ608_05510) 1198839..1199639 - 801 WP_256630519.1 translesion DNA synthesis-associated protein ImuA -
MJ608_RS05530 (MJ608_05515) 1199830..1200216 - 387 WP_256630520.1 VapC toxin family PIN domain ribonuclease Toxin
MJ608_RS05535 (MJ608_05520) 1200216..1200431 - 216 WP_256630521.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MJ608_RS05540 (MJ608_05525) 1200517..1201335 + 819 WP_256630522.1 SprT-like domain-containing protein -
MJ608_RS05545 (MJ608_05530) 1201650..1204061 - 2412 WP_256631247.1 heavy metal translocating P-type ATPase -
MJ608_RS05550 (MJ608_05535) 1204445..1205323 - 879 Protein_1079 copper homeostasis membrane protein CopD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 947395..1355908 408513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13815.14 Da        Isoelectric Point: 5.4798

>T237049 WP_256630520.1 NZ_CP092733:c1200216-1199830 [Comamonas thiooxydans]
MPVSVLVDTSVWVRHFREADTHLQELLMQDSVLMHSMVHAELACGTPPAPRADTLAALAMLRPSQEASIPETLAFLEKNM
LFGKGCGLVDLSLLASTLITPGALLWTADRRLAELAAQLGVAYAIPTH

Download         Length: 387 bp

>T237049 NZ_LR778147:c4579708-4579310 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTATTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7450.44 Da        Isoelectric Point: 6.2745

>AT237049 WP_256630521.1 NZ_CP092733:c1200431-1200216 [Comamonas thiooxydans]
MRSTFTIDDEVVNRARAVAAPGIAVPELVRLALETYTRVEAGKRLAALGGSAPDMPDVPRRGSAADAEGSR

Download         Length: 216 bp

>AT237049 NZ_LR778147:c4580004-4579711 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
AGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References