Detailed information of TA system TA237037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4861733..4862249
• Replicon: chromosome
• Accession: NZ_CP092717
• Organism: Klebsiella pneumoniae strain HvKp-su1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J2XDK6
• Locus tag: MKX18_RS23975
• Protein ID: WP_002886902.1
• Coordinates: 4861733..4862017 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: MKX18_RS23980
• Protein ID: WP_002886901.1
• Coordinates: 4862007..4862249 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKX18_RS23950 (MKX18_23945)	4857217..4857480	-	264	WP_004152271.1	PTS sugar transporter subunit IIB	-
MKX18_RS23955 (MKX18_23950)	4857610..4857783	+	174	WP_002886906.1	hypothetical protein	-
MKX18_RS23960 (MKX18_23955)	4857786..4858529	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
MKX18_RS23965 (MKX18_23960)	4858886..4861024	+	2139	WP_002886904.1	anaerobic ribonucleoside-triphosphate reductase	-
MKX18_RS23970 (MKX18_23965)	4861265..4861729	+	465	WP_002886903.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
MKX18_RS23975 (MKX18_23970)	4861733..4862017	-	285	WP_002886902.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MKX18_RS23980 (MKX18_23975)	4862007..4862249	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MKX18_RS23985 (MKX18_23980)	4862327..4864237	-	1911	WP_004152270.1	PRD domain-containing protein	-
MKX18_RS23990 (MKX18_23985)	4864260..4865414	-	1155	WP_002886900.1	lactonase family protein	-
MKX18_RS23995 (MKX18_23990)	4865480..4866220	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	sul1 / qacE / aadA2 / cmlA1 / ant(2'')-Ia	-	4811107..5020264	209157

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11125.95 Da
• Isoelectric Point: 10.3787

>T237037 WP_002886902.1 NZ_CP092717:c4862017-4861733 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T237037 NZ_LR778147:1524895-1525302 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT237037 WP_002886901.1 NZ_CP092717:c4862249-4862007 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT237037 NZ_LR778147:1524648-1524914 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GMH2

Antitoxin

• AlphaFold DB: A0A0H3GLP0