Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4861733..4862249 Replicon chromosome
Accession NZ_CP092717
Organism Klebsiella pneumoniae strain HvKp-su1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag MKX18_RS23975 Protein ID WP_002886902.1
Coordinates 4861733..4862017 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MKX18_RS23980 Protein ID WP_002886901.1
Coordinates 4862007..4862249 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKX18_RS23950 (MKX18_23945) 4857217..4857480 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
MKX18_RS23955 (MKX18_23950) 4857610..4857783 + 174 WP_002886906.1 hypothetical protein -
MKX18_RS23960 (MKX18_23955) 4857786..4858529 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MKX18_RS23965 (MKX18_23960) 4858886..4861024 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
MKX18_RS23970 (MKX18_23965) 4861265..4861729 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MKX18_RS23975 (MKX18_23970) 4861733..4862017 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKX18_RS23980 (MKX18_23975) 4862007..4862249 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MKX18_RS23985 (MKX18_23980) 4862327..4864237 - 1911 WP_004152270.1 PRD domain-containing protein -
MKX18_RS23990 (MKX18_23985) 4864260..4865414 - 1155 WP_002886900.1 lactonase family protein -
MKX18_RS23995 (MKX18_23990) 4865480..4866220 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element sul1 / qacE / aadA2 / cmlA1 / ant(2'')-Ia - 4811107..5020264 209157


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T237037 WP_002886902.1 NZ_CP092717:c4862017-4861733 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T237037 NZ_LR778147:1524895-1525302 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT237037 WP_002886901.1 NZ_CP092717:c4862249-4862007 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT237037 NZ_LR778147:1524648-1524914 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References