Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 329944..330794 | Replicon | chromosome II |
| Accession | NC_012580 | ||
| Organism | Vibrio cholerae M66-2 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9KM94 |
| Locus tag | VCM66_RS14820 | Protein ID | WP_000118351.1 |
| Coordinates | 330261..330794 (+) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | VCM66_RS14815 | Protein ID | WP_001909340.1 |
| Coordinates | 329944..330264 (+) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VCM66_RS14785 | 325280..325762 | + | 483 | WP_000422940.1 | GNAT family N-acetyltransferase | - |
| VCM66_RS14795 | 326570..326839 | + | 270 | WP_001114075.1 | DUF4160 domain-containing protein | - |
| VCM66_RS14800 | 326833..327354 | + | 522 | WP_000921692.1 | DUF2442 domain-containing protein | - |
| VCM66_RS18735 | 327411..327524 | + | 114 | WP_001894981.1 | hypothetical protein | - |
| VCM66_RS14805 | 327493..328329 | + | 837 | WP_000242986.1 | hypothetical protein | - |
| VCM66_RS14810 | 328494..329132 | + | 639 | WP_000230118.1 | HD domain-containing protein | - |
| VCM66_RS19275 | 329222..329382 | + | 161 | Protein_287 | DUF3709 domain-containing protein | - |
| VCM66_RS18740 | 329403..329624 | + | 222 | WP_012705854.1 | DUF3709 domain-containing protein | - |
| VCM66_RS14815 | 329944..330264 | + | 321 | WP_001909340.1 | DUF1778 domain-containing protein | Antitoxin |
| VCM66_RS14820 | 330261..330794 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | Toxin |
| VCM66_RS14825 | 331032..331310 | + | 279 | WP_000280324.1 | DUF3709 domain-containing protein | - |
| VCM66_RS18745 | 331711..331935 | + | 225 | WP_001894423.1 | DUF3709 domain-containing protein | - |
| VCM66_RS14835 | 332673..333062 | + | 390 | WP_000491263.1 | VOC family protein | - |
| VCM66_RS14840 | 333195..333710 | + | 516 | WP_000090008.1 | hypothetical protein | - |
| VCM66_RS14845 | 333851..334288 | + | 438 | WP_001202554.1 | NUDIX pyrophosphatase | - |
| VCM66_RS14850 | 334449..334796 | + | 348 | WP_000933409.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 305869..409778 | 103909 | |
| - | inside | Integron | - | - | 310949..409402 | 98453 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20171.46 Da Isoelectric Point: 9.1432
>T23703 WP_000118351.1 NC_012580:330261-330794 [Vibrio cholerae M66-2]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ
Download Length: 534 bp
>T23703 NC_012580:330261-330794 [Vibrio cholerae M66-2]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG
Antitoxin
Download Length: 107 a.a. Molecular weight: 11759.53 Da Isoelectric Point: 4.9309
>AT23703 WP_001909340.1 NC_012580:329944-330264 [Vibrio cholerae M66-2]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK
Download Length: 321 bp
>AT23703 NC_012580:329944-330264 [Vibrio cholerae M66-2]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|