237025

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 876332..876986 Replicon chromosome
Accession NZ_CP092717
Organism Klebsiella pneumoniae strain HvKp-su1

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag MKX18_RS04430 Protein ID WP_004144731.1
Coordinates 876579..876986 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MKX18_RS04425 Protein ID WP_002916312.1
Coordinates 876332..876598 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKX18_RS04400 (MKX18_04400) 871488..872921 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MKX18_RS04405 (MKX18_04405) 873040..873768 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MKX18_RS04410 (MKX18_04410) 873818..874129 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
MKX18_RS04415 (MKX18_04415) 874293..874952 + 660 WP_002916317.1 hemolysin III family protein -
MKX18_RS04420 (MKX18_04420) 875103..876086 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
MKX18_RS04425 (MKX18_04425) 876332..876598 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MKX18_RS04430 (MKX18_04430) 876579..876986 + 408 WP_004144731.1 protein YgfX Toxin
MKX18_RS04435 (MKX18_04435) 876993..877514 - 522 WP_002916308.1 flavodoxin FldB -
MKX18_RS04440 (MKX18_04440) 877615..878511 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MKX18_RS04445 (MKX18_04445) 878534..879247 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MKX18_RS04450 (MKX18_04450) 879253..880986 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T237025 WP_004144731.1 NZ_CP092717:876579-876986 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T237025 NZ_LR778146:3754616-3754891 [Escherichia coli]
ATGAGAACCCAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT237025 WP_002916312.1 NZ_CP092717:876332-876598 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237025 NZ_LR778146:3754888-3755247 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References