23702

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 326570..327354 Replicon chromosome II
Accession NC_012580
Organism Vibrio cholerae M66-2

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag VCM66_RS14795 Protein ID WP_001114075.1
Coordinates 326570..326839 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID C3LUY7
Locus tag VCM66_RS14800 Protein ID WP_000921692.1
Coordinates 326833..327354 (+) Length 174 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCM66_RS14765 321980..322279 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin -
VCM66_RS14770 322276..322518 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
VCM66_RS18700 322937..323014 + 78 WP_071908337.1 DUF645 family protein -
VCM66_RS19545 323018..323044 + 27 Protein_277 hypothetical protein -
VCM66_RS18715 323630..323773 + 144 WP_001900215.1 hypothetical protein -
VCM66_RS19260 323867..324046 + 180 Protein_279 DUF645 family protein -
VCM66_RS14780 324264..324692 + 429 WP_000620002.1 N-acetyltransferase -
VCM66_RS14785 325280..325762 + 483 WP_000422940.1 GNAT family N-acetyltransferase -
VCM66_RS14795 326570..326839 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
VCM66_RS14800 326833..327354 + 522 WP_000921692.1 DUF2442 domain-containing protein Antitoxin
VCM66_RS18735 327411..327524 + 114 WP_001894981.1 hypothetical protein -
VCM66_RS14805 327493..328329 + 837 WP_000242986.1 hypothetical protein -
VCM66_RS14810 328494..329132 + 639 WP_000230118.1 HD domain-containing protein -
VCM66_RS19275 329222..329382 + 161 Protein_287 DUF3709 domain-containing protein -
VCM66_RS18740 329403..329624 + 222 WP_012705854.1 DUF3709 domain-containing protein -
VCM66_RS14815 329944..330264 + 321 WP_001909340.1 DUF1778 domain-containing protein -
VCM66_RS14820 330261..330794 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
VCM66_RS14825 331032..331310 + 279 WP_000280324.1 DUF3709 domain-containing protein -
VCM66_RS18745 331711..331935 + 225 WP_001894423.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 305869..409778 103909
- inside Integron - - 310949..409402 98453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T23702 WP_001114075.1 NC_012580:326570-326839 [Vibrio cholerae M66-2]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T23702 NC_012580:326570-326839 [Vibrio cholerae M66-2]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19439.04 Da        Isoelectric Point: 6.7342

>AT23702 WP_000921692.1 NC_012580:326833-327354 [Vibrio cholerae M66-2]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT23702 NC_012580:326833-327354 [Vibrio cholerae M66-2]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure
AlphaFold DB C3LUY7

References