Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 51565..52166 | Replicon | plasmid pMFDS1011716 |
| Accession | NZ_CP092691 | ||
| Organism | Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011716 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A731GHK2 |
| Locus tag | MKV11_RS23870 | Protein ID | WP_001216038.1 |
| Coordinates | 51786..52166 (+) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | MKV11_RS23865 | Protein ID | WP_001190712.1 |
| Coordinates | 51565..51786 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKV11_RS23810 (MKV11_23805) | 46989..47192 | + | 204 | WP_000158003.1 | hypothetical protein | - |
| MKV11_RS23815 (MKV11_23810) | 47185..47424 | + | 240 | WP_000476201.1 | hypothetical protein | - |
| MKV11_RS23820 (MKV11_23815) | 47421..48146 | + | 726 | WP_000078034.1 | ead/Ea22-like family protein | - |
| MKV11_RS23825 (MKV11_23820) | 48148..48342 | + | 195 | WP_000224731.1 | hypothetical protein | - |
| MKV11_RS23830 (MKV11_23825) | 48344..48553 | + | 210 | WP_271232209.1 | hypothetical protein | - |
| MKV11_RS23835 (MKV11_23830) | 48550..49716 | + | 1167 | WP_000208025.1 | hypothetical protein | - |
| MKV11_RS23840 (MKV11_23835) | 49700..49984 | + | 285 | WP_001142397.1 | hypothetical protein | - |
| MKV11_RS23845 (MKV11_23840) | 49969..50319 | - | 351 | WP_001436207.1 | hypothetical protein | - |
| MKV11_RS23850 (MKV11_23845) | 50352..50450 | + | 99 | Protein_69 | DNA polymerase III subunit theta | - |
| MKV11_RS23855 (MKV11_23850) | 50510..50899 | + | 390 | WP_000506729.1 | S24 family peptidase | - |
| MKV11_RS23860 (MKV11_23855) | 51034..51456 | + | 423 | WP_000098854.1 | hypothetical protein | - |
| MKV11_RS23865 (MKV11_23860) | 51565..51786 | + | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MKV11_RS23870 (MKV11_23865) | 51786..52166 | + | 381 | WP_001216038.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| MKV11_RS23875 (MKV11_23870) | 52171..52368 | + | 198 | WP_000113017.1 | hypothetical protein | - |
| MKV11_RS23880 (MKV11_23875) | 52401..53177 | - | 777 | WP_271232210.1 | hypothetical protein | - |
| MKV11_RS23885 (MKV11_23880) | 53184..53861 | - | 678 | WP_001061874.1 | DUF2829 domain-containing protein | - |
| MKV11_RS23890 (MKV11_23885) | 53876..54370 | - | 495 | WP_000640907.1 | dUTP diphosphatase | - |
| MKV11_RS23895 (MKV11_23890) | 54367..54843 | - | 477 | WP_000861175.1 | hypothetical protein | - |
| MKV11_RS23900 (MKV11_23895) | 54840..55184 | - | 345 | WP_001191776.1 | hypothetical protein | - |
| MKV11_RS23905 (MKV11_23900) | 55258..56286 | - | 1029 | WP_001292235.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..92357 | 92357 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13574.27 Da Isoelectric Point: 5.1514
>T236963 WP_001216038.1 NZ_CP092691:51786-52166 [Salmonella enterica subsp. enterica serovar Thompson]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEISDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEISDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
Download Length: 381 bp
>T236963 NZ_LR778142:c2283792-2283690 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT236963 WP_001190712.1 NZ_CP092691:51565-51786 [Salmonella enterica subsp. enterica serovar Thompson]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT236963 NZ_LR778142:2283652-2283920 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A731GHK2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |