Detailed information of TA system TA023696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4561468..4561984
• Replicon: chromosome
• Accession: NC_012560
• Organism: Azotobacter vinelandii DJ

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M9YJX4
• Locus tag: AVIN_RS20515
• Protein ID: WP_012702982.1
• Coordinates: 4561468..4561749 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M9YN91
• Locus tag: AVIN_RS20520
• Protein ID: WP_012702983.1
• Coordinates: 4561739..4561984 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVIN_RS20495	4556510..4557160	+	651	WP_012702978.1	peptide-methionine (S)-S-oxide reductase MsrA	-
AVIN_RS20500	4557253..4557657	-	405	WP_041807414.1	VOC family protein	-
AVIN_RS25610	4557928..4558410	-	483	WP_012702980.1	AAA family ATPase	-
AVIN_RS20510	4558686..4561082	-	2397	WP_012702981.1	TonB-dependent siderophore receptor	-
AVIN_RS20515	4561468..4561749	-	282	WP_012702982.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AVIN_RS20520	4561739..4561984	-	246	WP_012702983.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
AVIN_RS20525	4562107..4563042	-	936	WP_012702984.1	FecR family protein	-
AVIN_RS20530	4563048..4563566	-	519	WP_012702985.1	RNA polymerase sigma factor	-
AVIN_RS20535	4564031..4564933	-	903	WP_012702987.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
AVIN_RS20540	4564980..4565870	-	891	WP_012702988.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-71)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10850.64 Da
• Isoelectric Point: 10.2902

>T23696 WP_012702982.1 NC_012560:c4561749-4561468 [Azotobacter vinelandii DJ]
MTYSLEFLPSALKEWEGLGHTLREQLKKKLRERLELPRVPADALRDMPNHYKIELRAAGYRLVYRVEDERVVVVVVAVGK
RERSAAYEKAKGR

Nucleotide

• Length: 282 bp

>T23696 NC_012560:c4561749-4561468 [Azotobacter vinelandii DJ]
ATGACCTATAGCCTGGAATTCCTGCCGTCCGCGCTGAAGGAGTGGGAGGGGCTGGGCCACACGTTGCGCGAGCAGTTGAA
GAAGAAACTGCGCGAGCGTCTGGAGTTGCCCAGGGTACCGGCCGATGCCCTGCGCGACATGCCGAATCACTACAAGATCG
AACTGCGCGCCGCGGGCTATCGCCTGGTGTACCGGGTAGAGGACGAGCGCGTGGTGGTGGTCGTGGTCGCTGTGGGCAAG
CGCGAACGCAGCGCGGCCTATGAGAAGGCTAAAGGACGGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8656.01 Da
• Isoelectric Point: 4.7023

>AT23696 WP_012702983.1 NC_012560:c4561984-4561739 [Azotobacter vinelandii DJ]
MQNVLADKAVSVSELKKNPSAVIGSAQGGPVAVLNHNRVMGYMVPAAVFEAMIERLEDLELAELARARANEKPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT23696 NC_012560:c4561984-4561739 [Azotobacter vinelandii DJ]
ATGCAAAACGTATTGGCCGACAAGGCCGTCAGCGTGTCCGAACTGAAAAAGAATCCGTCTGCCGTGATCGGCAGCGCCCA
AGGTGGGCCGGTAGCGGTGCTGAATCACAACCGGGTGATGGGTTACATGGTGCCGGCGGCGGTATTCGAAGCGATGATCG
AGCGCTTGGAGGACTTGGAGCTGGCCGAACTGGCTCGTGCCCGCGCCAATGAAAAGCCCGTGCCGGTGAGCCTGGATGAC
CTATAG

Structures

Toxin

• AlphaFold DB: M9YJX4

Antitoxin

• AlphaFold DB: M9YN91