Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4151023..4151539 Replicon chromosome
Accession NZ_CP092690
Organism Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011716

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag MKV11_RS20290 Protein ID WP_000220578.1
Coordinates 4151023..4151307 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag MKV11_RS20295 Protein ID WP_000212724.1
Coordinates 4151297..4151539 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKV11_RS20275 (4146139) 4146139..4147791 + 1653 WP_000155049.1 alpha,alpha-phosphotrehalase -
MKV11_RS20280 (4148200) 4148200..4150338 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
MKV11_RS20285 (4150555) 4150555..4151019 + 465 WP_017465840.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MKV11_RS20290 (4151023) 4151023..4151307 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKV11_RS20295 (4151297) 4151297..4151539 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MKV11_RS20300 (4151617) 4151617..4153530 - 1914 WP_001212135.1 BglG family transcription antiterminator -
MKV11_RS20305 (4153547) 4153547..4154287 - 741 WP_023193113.1 KDGP aldolase family protein -
MKV11_RS20310 (4154284) 4154284..4155402 - 1119 WP_017465839.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MKV11_RS20315 (4155386) 4155386..4156519 - 1134 WP_017465838.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T236959 WP_000220578.1 NZ_CP092690:c4151307-4151023 [Salmonella enterica subsp. enterica serovar Thompson]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T236959 NZ_LR778142:c973353-973135 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT236959 WP_000212724.1 NZ_CP092690:c4151539-4151297 [Salmonella enterica subsp. enterica serovar Thompson]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT236959 NZ_LR778142:c973753-973379 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References