Detailed information of TA system TA236955

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3434435..3435055
• Replicon: chromosome
• Accession: NZ_CP092690
• Organism: Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011716

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: MKV11_RS16950
• Protein ID: WP_001280991.1
• Coordinates: 3434837..3435055 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: MKV11_RS16945
• Protein ID: WP_000344807.1
• Coordinates: 3434435..3434809 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKV11_RS16935 (3429574)	3429574..3430767	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
MKV11_RS16940 (3430790)	3430790..3433939	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
MKV11_RS16945 (3434435)	3434435..3434809	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
MKV11_RS16950 (3434837)	3434837..3435055	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
MKV11_RS16955 (3435234)	3435234..3435785	+	552	WP_001278793.1	maltose O-acetyltransferase	-
MKV11_RS16960 (3435903)	3435903..3436373	+	471	WP_000136183.1	YlaC family protein	-
MKV11_RS16965 (3436429)	3436429..3436569	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
MKV11_RS16970 (3436575)	3436575..3436835	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
MKV11_RS16975 (3437060)	3437060..3438610	+	1551	WP_000213139.1	EAL domain-containing protein	-
MKV11_RS16985 (3438841)	3438841..3439230	+	390	WP_000961285.1	MGMT family protein	-
MKV11_RS16990 (3439263)	3439263..3439832	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T236955 WP_001280991.1 NZ_CP092690:3434837-3435055 [Salmonella enterica subsp. enterica serovar Thompson]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T236955 NZ_LR778141:c4992545-4992327 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT236955 WP_000344807.1 NZ_CP092690:3434435-3434809 [Salmonella enterica subsp. enterica serovar Thompson]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT236955 NZ_LR778141:c4992945-4992571 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0