Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3434435..3435055 Replicon chromosome
Accession NZ_CP092690
Organism Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011716

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MKV11_RS16950 Protein ID WP_001280991.1
Coordinates 3434837..3435055 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MKV11_RS16945 Protein ID WP_000344807.1
Coordinates 3434435..3434809 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKV11_RS16935 (3429574) 3429574..3430767 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MKV11_RS16940 (3430790) 3430790..3433939 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MKV11_RS16945 (3434435) 3434435..3434809 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MKV11_RS16950 (3434837) 3434837..3435055 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MKV11_RS16955 (3435234) 3435234..3435785 + 552 WP_001278793.1 maltose O-acetyltransferase -
MKV11_RS16960 (3435903) 3435903..3436373 + 471 WP_000136183.1 YlaC family protein -
MKV11_RS16965 (3436429) 3436429..3436569 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MKV11_RS16970 (3436575) 3436575..3436835 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MKV11_RS16975 (3437060) 3437060..3438610 + 1551 WP_000213139.1 EAL domain-containing protein -
MKV11_RS16985 (3438841) 3438841..3439230 + 390 WP_000961285.1 MGMT family protein -
MKV11_RS16990 (3439263) 3439263..3439832 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T236955 WP_001280991.1 NZ_CP092690:3434837-3435055 [Salmonella enterica subsp. enterica serovar Thompson]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T236955 NZ_LR778141:c4992545-4992327 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT236955 WP_000344807.1 NZ_CP092690:3434435-3434809 [Salmonella enterica subsp. enterica serovar Thompson]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT236955 NZ_LR778141:c4992945-4992571 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References