236944

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 845451..846076 Replicon chromosome
Accession NZ_CP092690
Organism Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011716

Toxin (Protein)


Gene name vapC Uniprot ID A0A5I5T1K0
Locus tag MKV11_RS04085 Protein ID WP_001748684.1
Coordinates 845678..846076 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag MKV11_RS04080 Protein ID WP_000557545.1
Coordinates 845451..845678 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKV11_RS04050 (840464) 840464..841981 + 1518 WP_000003339.1 lysine--tRNA ligase -
MKV11_RS04055 (842057) 842057..842602 - 546 WP_000133986.1 isopentenyl-diphosphate Delta-isomerase -
MKV11_RS04060 (842867) 842867..843625 + 759 WP_000244328.1 amidase activator ActS -
MKV11_RS04070 (843910) 843910..844716 - 807 WP_077907190.1 DUF1460 domain-containing protein -
MKV11_RS04075 (844991) 844991..845242 - 252 WP_001748683.1 hypothetical protein -
MKV11_RS04080 (845451) 845451..845678 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
MKV11_RS04085 (845678) 845678..846076 + 399 WP_001748684.1 tRNA(fMet)-specific endonuclease VapC Toxin
MKV11_RS04090 (846882) 846882..847418 + 537 WP_017465475.1 STM3031 family outer membrane protein -
MKV11_RS04095 (847465) 847465..848097 + 633 WP_000835265.1 YfdX family protein -
MKV11_RS04100 (848816) 848816..849403 + 588 WP_001244643.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 843910..855221 11311


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14995.39 Da        Isoelectric Point: 7.7780

>T236944 WP_001748684.1 NZ_CP092690:845678-846076 [Salmonella enterica subsp. enterica serovar Thompson]
MLKFMLDTNTCIFTIKNKPEHVKERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T236944 NZ_LR778141:2743693-2744070 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCATTCGCCGATGAACGTGTAATTGAGCAGCATATTG
AGGCCGGTATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGTCTGTACCCACTCTCAGTTAATAAACAGCATCGATATTCTACGGGCCCGCCGGGCAACCGGCCTGATGACCCGCAG
CAACTACAGAATGGTGAACGACATCACCCGGGGTAAACATTCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT236944 WP_000557545.1 NZ_CP092690:845451-845678 [Salmonella enterica subsp. enterica serovar Thompson]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT236944 NZ_LR778141:2743235-2743603 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCAGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5T1K0

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References