Detailed information of TA system TA236942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 315220..315806
• Replicon: chromosome
• Accession: NZ_CP092690
• Organism: Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011716

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A5V1HI31
• Locus tag: MKV11_RS01445
• Protein ID: WP_000174965.1
• Coordinates: 315438..315806 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A8F2ZY79
• Locus tag: MKV11_RS01440
• Protein ID: WP_001599562.1
• Coordinates: 315220..315441 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKV11_RS01415 (310240)	310240..311349	+	1110	WP_000822976.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
MKV11_RS01420 (311409)	311409..312335	+	927	WP_000003007.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
MKV11_RS01425 (312332)	312332..313609	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
MKV11_RS01430 (313606)	313606..314373	+	768	WP_017465331.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
MKV11_RS01435 (314375)	314375..315088	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
MKV11_RS01440 (315220)	315220..315441	+	222	WP_001599562.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MKV11_RS01445 (315438)	315438..315806	+	369	WP_000174965.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
MKV11_RS01450 (316065)	316065..317381	+	1317	WP_017465332.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
MKV11_RS01455 (317486)	317486..318373	+	888	WP_000094074.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
MKV11_RS01460 (318370)	318370..319215	+	846	WP_000572196.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
MKV11_RS01465 (319217)	319217..320287	+	1071	WP_000907838.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	312332..321024	8692

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (24-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13599.89 Da
• Isoelectric Point: 6.4657

>T236942 WP_000174965.1 NZ_CP092690:315438-315806 [Salmonella enterica subsp. enterica serovar Thompson]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLAISRGYIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Nucleotide

• Length: 369 bp

>T236942 NZ_LR778141:c2448332-2447997 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8151.20 Da
• Isoelectric Point: 6.4643

>AT236942 WP_001599562.1 NZ_CP092690:315220-315441 [Salmonella enterica subsp. enterica serovar Thompson]
MRTVNYSEARQNLAEVLESAVTGGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK

Nucleotide

• Length: 222 bp

>AT236942 NZ_LR778141:c2448580-2448332 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A5V1HI31