Detailed information of TA system TA236940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3216152..3216735
• Replicon: chromosome
• Accession: NZ_CP092689
• Organism: Gluconobacter frateurii strain ML.ISBL3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MKW11_RS14720
• Protein ID: WP_240284171.1
• Coordinates: 3216152..3216406 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MKW11_RS14725
• Protein ID: WP_240284172.1
• Coordinates: 3216403..3216735 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKW11_RS14690 (MKW11_14690)	3211458..3211757	-	300	WP_240284165.1	hypothetical protein	-
MKW11_RS14695 (MKW11_14695)	3211754..3212476	-	723	WP_240284166.1	hypothetical protein	-
MKW11_RS14700 (MKW11_14700)	3212476..3214203	-	1728	WP_240284167.1	hypothetical protein	-
MKW11_RS14705 (MKW11_14705)	3214364..3214747	-	384	WP_240284168.1	hypothetical protein	-
MKW11_RS14710 (MKW11_14710)	3214754..3215206	-	453	WP_240284169.1	DUF4065 domain-containing protein	-
MKW11_RS14715 (MKW11_14715)	3215340..3215834	-	495	WP_240284170.1	phosphate-starvation-inducible PsiE family protein	-
MKW11_RS14720 (MKW11_14720)	3216152..3216406	+	255	WP_240284171.1	type II toxin-antitoxin system HicA family toxin	Toxin
MKW11_RS14725 (MKW11_14725)	3216403..3216735	+	333	WP_240284172.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MKW11_RS14730 (MKW11_14730)	3217051..3217530	-	480	WP_240284173.1	hypothetical protein	-
MKW11_RS14735 (MKW11_14735)	3217530..3217964	-	435	WP_240284174.1	hypothetical protein	-
MKW11_RS14740 (MKW11_14740)	3217964..3219109	-	1146	WP_240284175.1	DUF3383 family protein	-
MKW11_RS14745 (MKW11_14745)	3219116..3219679	-	564	WP_240284176.1	hypothetical protein	-
MKW11_RS14750 (MKW11_14750)	3219646..3220017	-	372	WP_240284177.1	hypothetical protein	-
MKW11_RS14755 (MKW11_14755)	3220010..3220510	-	501	WP_240284178.1	hypothetical protein	-
MKW11_RS14760 (MKW11_14760)	3220510..3220956	-	447	WP_240284179.1	DUF4054 domain-containing protein	-
MKW11_RS14765 (MKW11_14765)	3220956..3221399	-	444	WP_240284180.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3207098..3269372	62274

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9423.86 Da
• Isoelectric Point: 10.6470

>T236940 WP_240284171.1 NZ_CP092689:3216152-3216406 [Gluconobacter frateurii]
MKAKHRRTLELIFKRPVSGNVAWGDIEALFTALGAEISEREGSRVGVFLFGEVRVFHRPHPKPDTDKGAVASVRKWLEEN
GVKP

Nucleotide

• Length: 255 bp

>T236940 NZ_LR778141:c1672324-1672073 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12016.59 Da
• Isoelectric Point: 4.6742

>AT236940 WP_240284172.1 NZ_CP092689:3216403-3216735 [Gluconobacter frateurii]
MNNTMTIDGHRAVIQFDPDLGMFRGEFLGLNGGADFYADSVERLIQEGETSLRVFLEMCTEKGIDPVKHYSGKFQVRVPE
EIHARAATAAAAKGVSLNQFVQEAIVEAAA

Nucleotide

• Length: 333 bp

>AT236940 NZ_LR778141:c1672076-1671822 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA