Detailed information of TA system TA236938

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 64985..65528
• Replicon: plasmid pIFL1_3
• Accession: NZ_CP092686
• Organism: Vibrio campbellii strain IFL1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U3AR50
• Locus tag: MKR81_RS28510
• Protein ID: WP_021709975.1
• Coordinates: 65232..65528 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MKR81_RS28505
• Protein ID: WP_050584455.1
• Coordinates: 64985..65242 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKR81_RS28485 (MKR81_28485)	62307..62888	+	582	WP_240307073.1	DUF2913 family protein	-
MKR81_RS28490 (MKR81_28490)	62896..63135	-	240	WP_240307074.1	hypothetical protein	-
MKR81_RS28495 (MKR81_28495)	63159..64094	-	936	WP_240307075.1	hypothetical protein	-
MKR81_RS28500 (MKR81_28500)	64279..64914	+	636	WP_240307076.1	recombinase family protein	-
MKR81_RS28505 (MKR81_28505)	64985..65242	+	258	WP_050584455.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MKR81_RS28510 (MKR81_28510)	65232..65528	+	297	WP_021709975.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MKR81_RS28515 (MKR81_28515)	66192..67091	-	900	WP_240307077.1	hypothetical protein	-
MKR81_RS28520 (MKR81_28520)	67650..68459	-	810	WP_240307078.1	VUT family protein	-
MKR81_RS28525 (MKR81_28525)	68428..68979	-	552	WP_045417674.1	helix-turn-helix transcriptional regulator	-
MKR81_RS28530 (MKR81_28530)	69345..69611	+	267	WP_045402091.1	hypothetical protein	-
MKR81_RS28535 (MKR81_28535)	69960..70139	+	180	WP_240307079.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..77175	77175

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11173.17 Da
• Isoelectric Point: 10.7229

>T236938 WP_021709975.1 NZ_CP092686:65232-65528 [Vibrio campbellii]
MTYKLKFDRKAKKAFDKLGEPVKSQFKAKLREVLTNPHIVGSALRGRLSGCYKLKLKSSGYRLVYKVEDGELTILVLAIG
KRERNEAYLKAEQSIARN

Nucleotide

• Length: 297 bp

>T236938 NZ_LR778141:c1461162-1461059 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9405.77 Da
• Isoelectric Point: 3.7078

>AT236938 WP_050584455.1 NZ_CP092686:64985-65242 [Vibrio campbellii]
MSMTHTILTDISAGITQLKADPMGVIEEANGAPVAILNRNKPAFYAIPCALFESMMEELENNQLMMMAEDALNRDDFVEV
DIDDL

Nucleotide

• Length: 258 bp

>AT236938 NZ_LR778141:1461021-1461292 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCTTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: U3AR50