Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1445144..1445703 | Replicon | chromosome |
| Accession | NZ_CP092682 | ||
| Organism | Vibrio campbellii strain IFL1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | MKR81_RS06840 | Protein ID | WP_240305336.1 |
| Coordinates | 1445144..1445422 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | MKR81_RS06845 | Protein ID | WP_005398409.1 |
| Coordinates | 1445419..1445703 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKR81_RS06790 (MKR81_06790) | 1440266..1440697 | + | 432 | WP_045412706.1 | hypothetical protein | - |
| MKR81_RS06795 (MKR81_06795) | 1440712..1440804 | + | 93 | WP_078535131.1 | DUF3265 domain-containing protein | - |
| MKR81_RS06800 (MKR81_06800) | 1440857..1441312 | + | 456 | WP_240305331.1 | NUDIX domain-containing protein | - |
| MKR81_RS06805 (MKR81_06805) | 1441309..1441419 | + | 111 | WP_072615040.1 | DUF3265 domain-containing protein | - |
| MKR81_RS06810 (MKR81_06810) | 1441447..1442355 | + | 909 | WP_240305333.1 | phosphotransferase | - |
| MKR81_RS06815 (MKR81_06815) | 1442893..1443022 | + | 130 | Protein_1268 | DUF3265 domain-containing protein | - |
| MKR81_RS06820 (MKR81_06820) | 1443552..1443641 | + | 90 | WP_080766723.1 | DUF3265 domain-containing protein | - |
| MKR81_RS06825 (MKR81_06825) | 1443677..1444579 | + | 903 | WP_021706454.1 | HNH endonuclease | - |
| MKR81_RS06830 (MKR81_06830) | 1444594..1444686 | + | 93 | WP_140107909.1 | DUF3265 domain-containing protein | - |
| MKR81_RS06835 (MKR81_06835) | 1444743..1444982 | + | 240 | WP_240305334.1 | hypothetical protein | - |
| MKR81_RS06840 (MKR81_06840) | 1445144..1445422 | - | 279 | WP_240305336.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MKR81_RS06845 (MKR81_06845) | 1445419..1445703 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| MKR81_RS06850 (MKR81_06850) | 1445899..1446321 | + | 423 | WP_238818746.1 | GNAT family N-acetyltransferase | - |
| MKR81_RS06855 (MKR81_06855) | 1446305..1446706 | + | 402 | WP_240305337.1 | hypothetical protein | - |
| MKR81_RS06860 (MKR81_06860) | 1447175..1447471 | + | 297 | WP_240305339.1 | hypothetical protein | - |
| MKR81_RS06865 (MKR81_06865) | 1447486..1447578 | + | 93 | WP_005445734.1 | DUF3265 domain-containing protein | - |
| MKR81_RS06870 (MKR81_06870) | 1448078..1448503 | + | 426 | WP_240305341.1 | hypothetical protein | - |
| MKR81_RS06875 (MKR81_06875) | 1448658..1449137 | + | 480 | WP_075714201.1 | GNAT family N-acetyltransferase | - |
| MKR81_RS06880 (MKR81_06880) | 1449281..1449685 | + | 405 | WP_103412993.1 | DUF1801 domain-containing protein | - |
| MKR81_RS06885 (MKR81_06885) | 1449839..1450243 | + | 405 | WP_240305342.1 | GFA family protein | - |
| MKR81_RS06890 (MKR81_06890) | 1450281..1450360 | + | 80 | Protein_1283 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1427914..1476323 | 48409 | |
| - | inside | Integron | - | - | 1426705..1471934 | 45229 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10877.50 Da Isoelectric Point: 4.2397
>T236936 WP_240305336.1 NZ_CP092682:c1445422-1445144 [Vibrio campbellii]
MILWEEESLNDRENIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDRENIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T236936 NZ_LR778141:1008531-1008707 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT236936 WP_005398409.1 NZ_CP092682:c1445703-1445419 [Vibrio campbellii]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT236936 NZ_LR778141:1008753-1009169 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|