Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 1555836..1556412 Replicon chromosome
Accession NZ_CP092672
Organism Leptospira interrogans strain FMAS_KG1

Toxin (Protein)


Gene name chpK Uniprot ID A0A8I0U3W7
Locus tag FH587_RS11200 Protein ID WP_000617905.1
Coordinates 1556071..1556412 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID -
Locus tag FH587_RS11195 Protein ID WP_002131273.1
Coordinates 1555836..1556084 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH587_RS11185 (FH587_11185) 1552975..1553434 - 460 Protein_1281 hypothetical protein -
FH587_RS11190 (FH587_11190) 1553588..1553884 + 297 WP_000477061.1 helix-turn-helix transcriptional regulator -
FH587_RS11195 (FH587_11195) 1555836..1556084 + 249 WP_002131273.1 ribbon-helix-helix domain-containing protein Antitoxin
FH587_RS11200 (FH587_11200) 1556071..1556412 + 342 WP_000617905.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FH587_RS11205 (FH587_11205) 1557436..1558428 - 993 WP_000041094.1 aldolase/citrate lyase family protein -
FH587_RS11210 (FH587_11210) 1558568..1559503 - 936 WP_000004531.1 ornithine carbamoyltransferase -
FH587_RS11215 (FH587_11215) 1560307..1560774 + 468 WP_000060052.1 hypothetical protein -
FH587_RS11220 (FH587_11220) 1560771..1561175 + 405 WP_001974506.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12212.13 Da        Isoelectric Point: 5.0939

>T236928 WP_000617905.1 NZ_CP092672:1556071-1556412 [Leptospira interrogans]
MIRGEIWLVDLGIPFGSEPGFKCPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVLISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD

Download         Length: 342 bp

>T236928 NZ_LR778140:c4347934-4347584 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9352.76 Da        Isoelectric Point: 10.3398

>AT236928 WP_002131273.1 NZ_CP092672:1555836-1556084 [Leptospira interrogans]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETKNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT236928 NZ_LR778140:c4348179-4347928 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References