236923

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 1021728..1022356 Replicon chromosome
Accession NZ_CP092663
Organism Leptospira interrogans strain FMAS_PN3

Toxin (Protein)


Gene name vapC Uniprot ID Q8F7E4
Locus tag FH598_RS04670 Protein ID WP_000281042.1
Coordinates 1021728..1022126 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8F7E3
Locus tag FH598_RS04675 Protein ID WP_001192482.1
Coordinates 1022126..1022356 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH598_RS04645 (FH598_04635) 1017460..1018227 + 768 WP_000636954.1 DUF1554 domain-containing protein -
FH598_RS04650 (FH598_04640) 1018746..1019606 + 861 WP_149792691.1 hypothetical protein -
FH598_RS04655 (FH598_04645) 1019862..1020938 - 1077 WP_001170569.1 hypothetical protein -
FH598_RS04660 (FH598_04650) 1021049..1021309 - 261 WP_239033688.1 hypothetical protein -
FH598_RS04665 (FH598_04655) 1021331..1021630 - 300 Protein_838 hypothetical protein -
FH598_RS04670 (FH598_04660) 1021728..1022126 - 399 WP_000281042.1 type II toxin-antitoxin system VapC family toxin Toxin
FH598_RS04675 (FH598_04665) 1022126..1022356 - 231 WP_001192482.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FH598_RS04680 (FH598_04670) 1022954..1023535 - 582 WP_137170912.1 hypothetical protein -
FH598_RS04685 (FH598_04675) 1023775..1024923 - 1149 WP_137170914.1 hypothetical protein -
FH598_RS04690 (FH598_04680) 1025108..1026223 - 1116 WP_000353261.1 protein kinase -
FH598_RS04695 (FH598_04685) 1026278..1026631 - 354 WP_149792689.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15139.76 Da        Isoelectric Point: 9.6893

>T236923 WP_000281042.1 NZ_CP092663:c1022126-1021728 [Leptospira interrogans]
MYLLDTNICIFLIKKKNATLLENLKKKLNKDLFVSSLTVAELEFGIQKSEFKEKNKVALIEFLTIFNILSFSDKDAESYG
IIRADLERKGNVIGSIDMLLAAQAIANNYIFVTNNTKEFKRIKALKIENWTQ

Download         Length: 399 bp

>T236923 NZ_LR778140:2790363-2790470 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8771.05 Da        Isoelectric Point: 8.6588

>AT236923 WP_001192482.1 NZ_CP092663:c1022356-1022126 [Leptospira interrogans]
MQTAKLFINGRSQAVRLPKEFQFTGDDVLIQKVGEAVILVPKNKAWNVFLEGLNGFSDDFFKEEREQPKSDKREKL

Download         Length: 231 bp

>AT236923 NZ_LR778140:c2790310-2790249 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6HAN6

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6HAF7

References