236921

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 1963923..1964499 Replicon chromosome
Accession NZ_CP092660
Organism Leptospira kirschneri strain FMAS_PN5

Toxin (Protein)


Gene name chpK Uniprot ID M6FCF3
Locus tag FH602_RS10790 Protein ID WP_004765542.1
Coordinates 1963923..1964264 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID A0A5F2E6L8
Locus tag FH602_RS10795 Protein ID WP_016762507.1
Coordinates 1964251..1964499 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH602_RS10775 (FH602_10775) 1959219..1959821 + 603 WP_004765472.1 riboflavin synthase -
FH602_RS10780 (FH602_10780) 1960510..1961715 + 1206 WP_004750307.1 bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II -
FH602_RS10785 (FH602_10785) 1962485..1963078 + 594 WP_004750378.1 hypothetical protein -
FH602_RS10790 (FH602_10790) 1963923..1964264 - 342 WP_004765542.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FH602_RS10795 (FH602_10795) 1964251..1964499 - 249 WP_016762507.1 hypothetical protein Antitoxin
FH602_RS10800 (FH602_10800) 1965375..1966286 - 912 WP_004765478.1 hypothetical protein -
FH602_RS10805 (FH602_10805) 1966347..1968812 - 2466 WP_004779354.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12393.35 Da        Isoelectric Point: 10.0986

>T236921 WP_004765542.1 NZ_CP092660:c1964264-1963923 [Leptospira kirschneri]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVLISKKDSNLSKDSVVNVSQLV
TLDKKRFLNKAGKLKSNKLDKVEVGLKLVTGLD

Download         Length: 342 bp

>T236921 NZ_LR778140:c2588996-2588820 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9329.72 Da        Isoelectric Point: 10.3019

>AT236921 WP_016762507.1 NZ_CP092660:c1964499-1964251 [Leptospira kirschneri]
MKTAISIPDELFKTAEKTAKKLGIPRSQLFAKALEEFIQSHSKESITEKLNKVYSSKSKETKNNITDLSIESLRKSLKND
SW

Download         Length: 249 bp

>AT236921 NZ_LR778140:c2588774-2588358 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTGACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2B3P5

Antitoxin

Source ID Structure
AlphaFold DB A0A5F2E6L8

References