236918

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4485702..4486321 Replicon chromosome
Accession NZ_CP092656
Organism Klebsiella pneumoniae strain NB5

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MJ642_RS25170 Protein ID WP_002892050.1
Coordinates 4486103..4486321 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MJ642_RS25165 Protein ID WP_002892066.1
Coordinates 4485702..4486076 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ642_RS25155 4480854..4482047 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MJ642_RS25160 4482070..4485216 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MJ642_RS25165 4485702..4486076 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MJ642_RS25170 4486103..4486321 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MJ642_RS25175 4486480..4487046 + 567 WP_002892030.1 maltose O-acetyltransferase -
MJ642_RS25180 4487018..4487158 - 141 WP_004147370.1 hypothetical protein -
MJ642_RS25185 4487179..4487649 + 471 WP_002892026.1 YlaC family protein -
MJ642_RS25190 4487624..4489075 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
MJ642_RS25195 4489176..4489874 + 699 WP_002892021.1 GNAT family protein -
MJ642_RS25200 4489871..4490011 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MJ642_RS25205 4490011..4490274 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T236918 WP_002892050.1 NZ_CP092656:4486103-4486321 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T236918 NZ_LR778140:1966948-1967202 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT236918 WP_002892066.1 NZ_CP092656:4485702-4486076 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT236918 NZ_LR778140:1966700-1966951 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References