Detailed information of TA system TA236900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3964013..3964712
• Replicon: chromosome
• Accession: NZ_CP092652
• Organism: Proteus mirabilis strain PM8762

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MJ616_RS18485
• Protein ID: WP_017628658.1
• Coordinates: 3964013..3964399 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: MJ616_RS18490
• Protein ID: WP_004246828.1
• Coordinates: 3964392..3964712 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ616_RS18470	3960032..3960613	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
MJ616_RS18475	3960864..3961769	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
MJ616_RS18480	3961779..3963851	+	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
MJ616_RS18485	3964013..3964399	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MJ616_RS18490	3964392..3964712	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
MJ616_RS18495	3964761..3965195	-	435	WP_004246827.1	hypothetical protein	-
MJ616_RS18500	3965188..3966072	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
MJ616_RS18505	3966287..3967573	-	1287	WP_063073863.1	DUF3748 domain-containing protein	-
MJ616_RS18510	3967710..3968327	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
MJ616_RS18515	3968628..3969251	+	624	WP_004246821.1	guanylate kinase	-
MJ616_RS18520	3969306..3969581	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T236900 WP_017628658.1 NZ_CP092652:3964013-3964399 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T236900 NZ_LR745045:c4768263-4767979 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT236900 WP_004246828.1 NZ_CP092652:3964392-3964712 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT236900 NZ_LR745045:c4768495-4768253 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: B4EZ97