Detailed information of TA system TA236899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3589584..3591306
• Replicon: chromosome
• Accession: NZ_CP092652
• Organism: Proteus mirabilis strain PM8762

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A0U2S2I2
• Locus tag: MJ616_RS16840
• Protein ID: WP_064497040.1
• Coordinates: 3589584..3590522 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A934MVJ4
• Locus tag: MJ616_RS16845
• Protein ID: WP_000095577.1
• Coordinates: 3590515..3591306 (-)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ616_RS16820	3585525..3586037	-	513	WP_175215521.1	S26 family signal peptidase	-
MJ616_RS16825	3586021..3586368	-	348	WP_064497038.1	hypothetical protein	-
MJ616_RS16830	3586361..3588760	-	2400	WP_064497039.1	type IV secretion system protein TraC	-
MJ616_RS16835	3588760..3589452	-	693	WP_001228924.1	DsbC family protein	-
MJ616_RS16840	3589584..3590522	-	939	WP_064497040.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
MJ616_RS16845	3590515..3591306	-	792	WP_000095577.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
MJ616_RS16850	3591527..3591913	-	387	WP_032469918.1	TraA family conjugative transfer protein	-
MJ616_RS16855	3591910..3592482	-	573	WP_024008834.1	type IV conjugative transfer system lipoprotein TraV	-
MJ616_RS16860	3592557..3593846	-	1290	WP_064497041.1	TraB/VirB10 family protein	-
MJ616_RS16865	3593849..3594745	-	897	WP_064497055.1	type-F conjugative transfer system secretin TraK	-
MJ616_RS16870	3594729..3595355	-	627	WP_064497042.1	TraE/TraK family type IV conjugative transfer system protein	-
MJ616_RS16875	3595352..3595633	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J) / aadA2 / ere(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / blaCTX-M-65 / aph(3')-Ia / tet(C) / aph(3'')-Ib / aph(6)-Id	-	3460482..3636040	175558

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-272)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35542.81 Da
• Isoelectric Point: 4.9912

>T236899 WP_064497040.1 NZ_CP092652:c3590522-3589584 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T236899 NZ_LR745045:4705850-4706785 [Klebsiella pneumoniae]
CTGCTTTTTTCTGATGTAACAGATGCTCTTGGTATTGAGTCCGGCGCTATTGTAGAAAAAGATCACTATATCGTTGAGCT
TTTACATTTACTGAAACCGCTAACATTTGACACTCATCAATTGCTGTTTGCCGGAGGAACTGCACTGGCAAAATCGGGCA
TTGTGCTTAACCGAATGTCGGAAGATGTAGATATAAAACTGGTACCCACAGATACTTTCTTGTCTCTTTCGCGCACCCAG
CGCAAAGGTATTCGTAAAGAGATCGTCCAGACAATTTCTCATGCAATAACTGCAACAGACATGTTCAGCTTTGACGATGC
CCATCCAAAAGTGACGCGGGATGAATATCGTTACAACGACATACCCGTTCGCTATCCGCAGCGGGTAGCGCAAGCACCTT
GCCTGCGTCCTTTTATCCAGTTGGAATTGATGGAAGCAAATTTGCTTGAGGCACCAGAGTTCAGGGATATTCATACACTG
GTGACGACACTTACTGGAAAAGCACCTGTCATTTCAGCCTTCCCCTGCGCCACAATTATCAGTACTCAGGCAGAAAAACT
GGTGGCTATGCTGCGCCGTACTGCAGCAGTTGCGCGTAATATTGAACGCCAGGATGACGCTTCGCTGGTACGTCATATCT
ACGACACATATTGTATCGTGCAGGCAGGCAATGTTGATATGTGTTTGCTTACTGATTTTTTTAAGCAAACCATTGAGCAA
GATATCCAGCGTTATGGCAATCAGTATCCGCAGTTTTGTGTTTCACCAAATGATGAGCTAAAAATGGGGCTGGACGAACT
TGAGCATAACCCGCTTTATAAGACACGCTACCAGCAATTTGTTGCCCCAATGGTATATGGTGCTCGCAAGGTATCGTGGG
ATGAAGCGTATGCTTCCTTTCGTCAAATGGCGTTAATAATTCTAGATACTTACTAA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30109.49 Da
• Isoelectric Point: 9.5097

>AT236899 WP_000095577.1 NZ_CP092652:c3591306-3590515 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT236899 NZ_LR745045:4705448-4705843 [Klebsiella pneumoniae]
ATGACGATAAAAACACGCATTCAGTCACGACTGAAACGCTCAAAACGCTATGTATTCACTCGTGACGATTTCAAGGATAT
TGCAGGCTATGATCAGATTGGCAGGGTATTGCGCGACCTTCTCAAAGAGGGGCAACTACTGAAGGTGGGCTACGGTGTGT
ACACCAAAGCGCGTCGGAACAGCATTACTGGAAAAGTCATGCCCGCAGCACCAAGGGGATCTTCGGCAGTGATCGTTGAA
ACGCTGGAGCGCCTGAAAGTACGTTACCGCTATGAAGGAGCTACACAGACATATAATAGTGGCGAATCCACGCAAATCCC
CGTGTCACCGGAGATCAAAACATCTCCGCGCTTTAAACGCGCGTTGTCTGTGGGGAACAGCAAACTAAATGGATAA

Structures

Toxin

• AlphaFold DB: A0A0U2S2I2