Detailed information of TA system TA236897

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1959406..1960205
• Replicon: chromosome
• Accession: NZ_CP092652
• Organism: Proteus mirabilis strain PM8762

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E3RD10
• Locus tag: MJ616_RS09460
• Protein ID: WP_004247966.1
• Coordinates: 1959681..1960205 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: B4EVS2
• Locus tag: MJ616_RS09455
• Protein ID: WP_004247964.1
• Coordinates: 1959406..1959684 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ616_RS09430	1954756..1955838	+	1083	WP_004242680.1	peptide chain release factor 1	-
MJ616_RS09435	1955838..1956686	+	849	WP_004247962.1	peptide chain release factor N(5)-glutamine methyltransferase	-
MJ616_RS09440	1956664..1957479	+	816	WP_004242688.1	invasion regulator SirB1	-
MJ616_RS09445	1957537..1958391	+	855	WP_004242689.1	3-deoxy-8-phosphooctulonate synthase	-
MJ616_RS09450	1958399..1959328	+	930	WP_017628160.1	TIGR01212 family radical SAM protein	-
MJ616_RS09455	1959406..1959684	+	279	WP_004247964.1	DUF1778 domain-containing protein	Antitoxin
MJ616_RS09460	1959681..1960205	+	525	WP_004247966.1	hypothetical protein	Toxin
MJ616_RS09465	1960286..1961986	-	1701	WP_017628159.1	C4-dicarboxylic acid transporter DauA	-
MJ616_RS09475	1962950..1963891	+	942	WP_004242695.1	glyoxylate/hydroxypyruvate reductase GhrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (5-87)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19192.12 Da
• Isoelectric Point: 9.3561

>T236897 WP_004247966.1 NZ_CP092652:1959681-1960205 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Nucleotide

• Length: 525 bp

>T236897 NZ_LR745045:4044761-4044979 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10252.82 Da
• Isoelectric Point: 5.1369

>AT236897 WP_004247964.1 NZ_CP092652:1959406-1959684 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Nucleotide

• Length: 279 bp

>AT236897 NZ_LR745045:4044360-4044734 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: B4EVS2