Detailed information of TA system TA023689

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2178890..2179773
• Replicon: chromosome
• Accession: NC_012560
• Organism: Azotobacter vinelandii DJ

Toxin (Protein)

• Gene name: -
• Uniprot ID: M9YQ68
• Locus tag: AVIN_RS09985
• Protein ID: WP_012700772.1
• Coordinates: 2179336..2179773 (+)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: PrcA
• Uniprot ID: M9YEX5
• Locus tag: AVIN_RS09980
• Protein ID: WP_012700771.1
• Coordinates: 2178890..2179339 (+)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AVIN_RS09955	2174122..2174436	-	315	Protein_1985	TonB-dependent receptor	-
AVIN_RS09970	2175487..2177439	-	1953	WP_081434881.1	TonB-dependent receptor	-
AVIN_RS09975	2177647..2178690	+	1044	WP_175556059.1	LacI family DNA-binding transcriptional regulator	-
AVIN_RS09980	2178890..2179339	+	450	WP_012700771.1	DUF2384 domain-containing protein	Antitoxin
AVIN_RS09985	2179336..2179773	+	438	WP_012700772.1	RES family NAD+ phosphorylase	Toxin
AVIN_RS09990	2179794..2180195	-	402	WP_012699476.1	biopolymer transporter ExbD	-
AVIN_RS09995	2180197..2180907	-	711	WP_012700773.1	MotA/TolQ/ExbB proton channel family protein	-
AVIN_RS10000	2180941..2181801	-	861	WP_012700774.1	energy transducer TonB	-
AVIN_RS10005	2181934..2183043	-	1110	WP_012700775.1	LLM class flavin-dependent oxidoreductase	-
AVIN_RS10010	2183439..2183642	-	204	WP_012700776.1	hypothetical protein	-
AVIN_RS10015	2183773..2184636	-	864	WP_012700777.1	TauD/TfdA family dioxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2174450..2174785	335

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-140)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (97-143)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15778.14 Da
• Isoelectric Point: 4.7182

>T23689 WP_012700772.1 NC_012560:2179336-2179773 [Azotobacter vinelandii DJ]
VILWRISAYADLGGVGGLRASGRWHHIGRPVVYAAESPAGAMLEVLVHLEIDPEDFPATLQLIRIELPDPVSLAELAPLP
ENWKSDPEATRAIGDRFLDTRSALLLPVPSAIIPCTTNYLFNPVHPEASGASIRVEQFPLDARLV

Nucleotide

• Length: 438 bp

>T23689 NC_012560:2179336-2179773 [Azotobacter vinelandii DJ]
GTGATCCTCTGGCGGATCAGCGCCTACGCCGATCTCGGCGGAGTCGGCGGCTTGCGCGCCAGCGGCCGCTGGCATCATAT
CGGCAGGCCGGTCGTCTATGCGGCGGAAAGCCCGGCCGGGGCGATGCTGGAGGTGCTCGTCCATCTGGAAATCGATCCCG
AGGACTTCCCGGCGACGCTGCAGTTGATCCGCATCGAGCTTCCGGATCCGGTTTCGCTGGCCGAACTCGCGCCGCTGCCG
GAGAACTGGAAGTCCGACCCGGAAGCCACCCGCGCCATCGGCGACCGGTTTCTGGATACGAGGAGCGCCCTGCTGCTCCC
GGTACCCAGTGCCATCATCCCCTGCACGACCAACTATCTGTTCAACCCCGTACATCCCGAAGCCAGCGGCGCGAGCATCC
GGGTGGAGCAGTTTCCCCTCGACGCCCGGCTCGTCTGA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 17036.65 Da
• Isoelectric Point: 6.7346

>AT23689 WP_012700771.1 NC_012560:2178890-2179339 [Azotobacter vinelandii DJ]
MLAEVLRDHGYTAYRVRLRSLLDIPESATDFEIHTRITQGFPAARLMQLTEAGVVTPLERDQIIPLRTLKSRIERDQPLT
VEESDRFFRAAHITAMAEAVFGDREKARRWLSKPKERFSGLTPMQMLTTQQGTAQVEEMLLQIVEGLAL

Nucleotide

• Length: 450 bp

>AT23689 NC_012560:2178890-2179339 [Azotobacter vinelandii DJ]
ATGCTTGCCGAAGTGCTGCGTGACCACGGCTATACCGCGTACCGGGTGCGTCTTCGCAGTCTGCTGGACATTCCCGAGTC
GGCAACCGACTTCGAGATCCACACCCGGATTACCCAGGGCTTTCCCGCGGCACGCCTGATGCAGTTGACCGAGGCCGGGG
TTGTCACGCCACTGGAGCGCGACCAGATCATTCCCCTGCGCACCCTCAAGAGCCGCATCGAGCGCGATCAGCCGCTGACC
GTGGAGGAAAGCGACAGGTTCTTTCGCGCCGCTCACATCACGGCGATGGCCGAAGCCGTCTTCGGCGATCGCGAAAAGGC
CAGGCGCTGGCTTTCCAAACCCAAGGAGCGGTTTTCCGGCCTGACTCCCATGCAGATGCTCACCACCCAGCAGGGCACCG
CTCAGGTGGAAGAAATGTTGCTGCAGATCGTCGAAGGCCTGGCCTTGTGA

Structures

Toxin

• AlphaFold DB: M9YQ68

Antitoxin

• AlphaFold DB: M9YEX5