Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1070233..1070852 Replicon chromosome
Accession NZ_CP092648
Organism Klebsiella pneumoniae strain KP7728

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MJ615_RS05185 Protein ID WP_002892050.1
Coordinates 1070233..1070451 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MJ615_RS05190 Protein ID WP_002892066.1
Coordinates 1070478..1070852 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ615_RS05150 (1066280) 1066280..1066543 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
MJ615_RS05155 (1066543) 1066543..1066683 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MJ615_RS05160 (1066680) 1066680..1067378 - 699 WP_002892021.1 GNAT family protein -
MJ615_RS05165 (1067479) 1067479..1068930 + 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
MJ615_RS05170 (1068905) 1068905..1069375 - 471 WP_002892026.1 YlaC family protein -
MJ615_RS05175 (1069396) 1069396..1069536 + 141 WP_004147370.1 hypothetical protein -
MJ615_RS05180 (1069508) 1069508..1070074 - 567 WP_002892030.1 maltose O-acetyltransferase -
MJ615_RS05185 (1070233) 1070233..1070451 - 219 WP_002892050.1 HHA domain-containing protein Toxin
MJ615_RS05190 (1070478) 1070478..1070852 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MJ615_RS05195 (1071338) 1071338..1074484 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MJ615_RS05200 (1074507) 1074507..1075700 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T236876 WP_002892050.1 NZ_CP092648:c1070451-1070233 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T236876 NZ_LR740777:114256-114672 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT236876 WP_002892066.1 NZ_CP092648:c1070852-1070478 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT236876 NZ_LR740777:114029-114259 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References