Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3774412..3775030 Replicon chromosome
Accession NZ_CP092647
Organism Escherichia coli strain EC5502

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag MJ614_RS20380 Protein ID WP_001291435.1
Coordinates 3774412..3774630 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E9TLB8
Locus tag MJ614_RS20385 Protein ID WP_000344794.1
Coordinates 3774656..3775030 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ614_RS20345 (3769702) 3769702..3770274 + 573 WP_000779831.1 YbaY family lipoprotein -
MJ614_RS20350 (3770305) 3770305..3770616 - 312 WP_000409911.1 MGMT family protein -
MJ614_RS20360 (3770995) 3770995..3771348 + 354 WP_000878140.1 DUF1428 domain-containing protein -
MJ614_RS20365 (3771390) 3771390..3772940 - 1551 WP_001364591.1 cyclic-guanylate-specific phosphodiesterase PdeB -
MJ614_RS20370 (3773104) 3773104..3773574 - 471 WP_000136192.1 YlaC family protein -
MJ614_RS20375 (3773690) 3773690..3774241 - 552 WP_000102564.1 maltose O-acetyltransferase -
MJ614_RS20380 (3774412) 3774412..3774630 - 219 WP_001291435.1 HHA domain-containing protein Toxin
MJ614_RS20385 (3774656) 3774656..3775030 - 375 WP_000344794.1 Hha toxicity modulator TomB Antitoxin
MJ614_RS20390 (3775576) 3775576..3778725 - 3150 WP_001132470.1 efflux RND transporter permease AcrB -
MJ614_RS20395 (3778748) 3778748..3779941 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T236868 WP_001291435.1 NZ_CP092647:c3774630-3774412 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T236868 NZ_LR740776:4646870-4647043 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14527.36 Da        Isoelectric Point: 4.9284

>AT236868 WP_000344794.1 NZ_CP092647:c3775030-3774656 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGRVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT236868 NZ_LR740776:4646546-4646842 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References