Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3140624..3141459 Replicon chromosome
Accession NZ_CP092647
Organism Escherichia coli strain EC5502

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2S4A272
Locus tag MJ614_RS17400 Protein ID WP_001094443.1
Coordinates 3141082..3141459 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag MJ614_RS17395 Protein ID WP_001285607.1
Coordinates 3140624..3140992 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ614_RS17360 (3136516) 3136516..3137196 + 681 WP_001282919.1 WYL domain-containing protein -
MJ614_RS17365 (3137344) 3137344..3138021 + 678 WP_001097301.1 hypothetical protein -
MJ614_RS17370 (3138027) 3138027..3138260 + 234 WP_001278287.1 DUF905 family protein -
MJ614_RS17375 (3138350) 3138350..3139168 + 819 WP_001175163.1 DUF932 domain-containing protein -
MJ614_RS17380 (3139260) 3139260..3139745 + 486 WP_000206664.1 antirestriction protein -
MJ614_RS17385 (3139760) 3139760..3140236 + 477 WP_001186165.1 RadC family protein -
MJ614_RS17390 (3140323) 3140323..3140544 + 222 WP_000692350.1 DUF987 domain-containing protein -
MJ614_RS17395 (3140624) 3140624..3140992 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MJ614_RS17400 (3141082) 3141082..3141459 + 378 WP_001094443.1 TA system toxin CbtA family protein Toxin
MJ614_RS17405 (3141456) 3141456..3141944 + 489 WP_000761685.1 DUF5983 family protein -
MJ614_RS17410 (3141964) 3141964..3142161 + 198 WP_001327226.1 DUF957 domain-containing protein -
MJ614_RS17415 (3142246) 3142246..3142389 + 144 Protein_3024 hypothetical protein -
MJ614_RS17420 (3142854) 3142854..3144119 + 1266 WP_001218329.1 integrase arm-type DNA-binding domain-containing protein -
MJ614_RS17425 (3144320) 3144320..3145789 - 1470 WP_001022619.1 serine/threonine-protein kinase -
MJ614_RS17430 (3145786) 3145786..3146328 - 543 WP_001115385.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(B) fimB / fimE / fimA / fimI / fimC 3097313..3172749 75436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.97 Da        Isoelectric Point: 7.3523

>T236865 WP_001094443.1 NZ_CP092647:3141082-3141459 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T236865 NZ_LR740776:c3166573-3166166 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT236865 WP_001285607.1 NZ_CP092647:3140624-3140992 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT236865 NZ_LR740776:c3166820-3166554 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4A272

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References