Detailed information of TA system TA023686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1682625..1683144
• Replicon: chromosome
• Accession: NC_012559
• Organism: Laribacter hongkongensis HLHK9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C1D8F6
• Locus tag: LHK_RS08005
• Protein ID: WP_012697232.1
• Coordinates: 1682625..1682912 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C1D8F7
• Locus tag: LHK_RS08010
• Protein ID: WP_012697233.1
• Coordinates: 1682899..1683144 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHK_RS07985	1678520..1678912	-	393	WP_012697228.1	hypothetical protein	-
LHK_RS07990	1678912..1679388	-	477	WP_012697229.1	DUF1833 family protein	-
LHK_RS07995	1679428..1679778	-	351	WP_143714547.1	hypothetical protein	-
LHK_RS08000	1679778..1682558	-	2781	WP_012697231.1	phage tail tape measure protein	-
LHK_RS08005	1682625..1682912	-	288	WP_012697232.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LHK_RS08010	1682899..1683144	-	246	WP_012697233.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LHK_RS08015	1683280..1683585	-	306	WP_052292567.1	DUF1799 domain-containing protein	-
LHK_RS08020	1683591..1683902	-	312	WP_012697235.1	hypothetical protein	-
LHK_RS08025	1683917..1684567	-	651	WP_012697236.1	phage tail protein	-
LHK_RS08030	1684628..1684981	-	354	WP_012697237.1	DUF3168 domain-containing protein	-
LHK_RS08035	1684968..1685513	-	546	WP_012697238.1	HK97 gp10 family phage protein	-
LHK_RS08040	1685510..1685815	-	306	WP_012697239.1	phage head closure protein	-
LHK_RS08045	1685812..1686111	-	300	WP_012697241.1	head-tail connector protein	-
LHK_RS08050	1686123..1686359	-	237	WP_012697240.1	hypothetical protein	-
LHK_RS08055	1686405..1687646	-	1242	WP_012697242.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1650379..1717618	67239

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-70)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10974.86 Da
• Isoelectric Point: 10.2971

>T23686 WP_012697232.1 NC_012559:c1682912-1682625 [Laribacter hongkongensis HLHK9]
MTTYKLRFHELALAEWNRLDGSIKAQLKKKLAERLVNPCVPSAQLSGMKDCYKIKLRSLGYRLVYRVDGNEVFVTVISIG
RRERNEAYIAATERL

Nucleotide

• Length: 288 bp

>T23686 NC_012559:c1682912-1682625 [Laribacter hongkongensis HLHK9]
TTGACGACCTATAAGCTGCGCTTTCACGAACTGGCACTGGCTGAATGGAACCGGCTTGACGGGTCAATCAAGGCACAGCT
CAAAAAGAAACTGGCCGAGAGACTCGTCAATCCGTGTGTGCCGTCAGCACAACTGTCCGGGATGAAGGACTGCTACAAGA
TCAAGCTGCGTAGCCTCGGCTATCGGCTGGTCTACCGCGTGGACGGGAATGAGGTCTTTGTGACAGTCATATCAATCGGC
CGGCGTGAGCGAAACGAGGCCTACATCGCCGCCACCGAGCGTCTGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8877.00 Da
• Isoelectric Point: 4.5494

>AT23686 WP_012697233.1 NC_012559:c1683144-1682899 [Laribacter hongkongensis HLHK9]
MHAIHADVTVSVTELKRSPSAIIEQAGNSPVAILNHNRPAAYLLSAELFESILDRLEDAQDVKLARERANGPFVEVNLDD
L

Nucleotide

• Length: 246 bp

>AT23686 NC_012559:c1683144-1682899 [Laribacter hongkongensis HLHK9]
ATGCACGCCATCCACGCCGACGTCACGGTAAGCGTCACCGAGCTGAAGCGCAGTCCTTCTGCCATCATCGAGCAGGCAGG
AAACAGCCCGGTTGCCATCCTCAACCACAACCGGCCGGCCGCCTACCTGCTCTCGGCAGAGCTGTTTGAAAGCATTCTTG
ACCGGCTGGAGGATGCGCAGGACGTGAAGCTGGCGCGAGAGCGCGCCAACGGCCCGTTTGTCGAGGTGAACCTTGACGAC
CTATAA

Structures

Toxin

• AlphaFold DB: C1D8F6

Antitoxin

• AlphaFold DB: C1D8F7