Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 2162799..2163386 Replicon chromosome
Accession NZ_CP092644
Organism Streptomyces sp. SCSIO ZS0520

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag MID12_RS07830 Protein ID WP_263172960.1
Coordinates 2162799..2163164 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag MID12_RS07835 Protein ID WP_040256563.1
Coordinates 2163189..2163386 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MID12_RS07810 2159125..2160516 - 1392 WP_040248332.1 diaminopimelate decarboxylase -
MID12_RS07815 2160529..2160651 - 123 WP_257786918.1 hypothetical protein -
MID12_RS07820 2160648..2161790 - 1143 WP_263165610.1 DALR anticodon-binding domain-containing protein -
MID12_RS07825 2162011..2162649 + 639 WP_263165613.1 hypothetical protein -
MID12_RS07830 2162799..2163164 - 366 WP_263172960.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MID12_RS07835 2163189..2163386 - 198 WP_040256563.1 hypothetical protein Antitoxin
MID12_RS07845 2164244..2164699 + 456 WP_263165615.1 response regulator -
MID12_RS07850 2165082..2165738 + 657 WP_263165617.1 HAD family hydrolase -
MID12_RS07855 2165883..2167505 - 1623 WP_263165619.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(19-79)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 12885.46 Da        Isoelectric Point: 4.3628

>T236844 WP_263172960.1 NZ_CP092644:c2163164-2162799 [Streptomyces sp. SCSIO ZS0520]
MDANDVIQIAEITLGGRVGVRDWGLLQSAVARPQSSVFGEDAYPTLFEKAAALLHSLSSNHSLVDGNKRTGWASAVVFLD
INGHSLKEPLDEDAAEEFVLAVAQSQLATPEIAGRLPGFVQ

Download         Length: 366 bp

>T236844 NZ_LR740759:c138655-138239 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7077.28 Da        Isoelectric Point: 10.9211

>AT236844 WP_040256563.1 NZ_CP092644:c2163386-2163189 [Streptomyces sp. SCSIO ZS0520]
MPALNVTFTDDEMAMLRDQAAKEDVSMKALAHSAILAEVHRRKVTAAAIRTARISAGLNKRLATK

Download         Length: 198 bp

>AT236844 NZ_LR740759:c138882-138652 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References