Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4008429..4009024 Replicon chromosome
Accession NZ_CP092639
Organism Escherichia coli strain HS

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag MJ392_RS19300 Protein ID WP_000239579.1
Coordinates 4008429..4008779 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag MJ392_RS19305 Protein ID WP_001223208.1
Coordinates 4008773..4009024 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ392_RS19280 (4003875) 4003875..4004897 - 1023 WP_001296689.1 ABC transporter permease -
MJ392_RS19285 (4004911) 4004911..4006413 - 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
MJ392_RS19290 (4006553) 4006553..4007509 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
MJ392_RS19295 (4007819) 4007819..4008349 + 531 WP_000055075.1 inorganic diphosphatase -
MJ392_RS19300 (4008429) 4008429..4008779 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
MJ392_RS19305 (4008773) 4008773..4009024 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
MJ392_RS19310 (4009236) 4009236..4009577 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
MJ392_RS19315 (4009580) 4009580..4013359 - 3780 WP_000060852.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T236842 WP_000239579.1 NZ_CP092639:c4008779-4008429 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T236842 NZ_LR740759:55754-55936 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT236842 WP_001223208.1 NZ_CP092639:c4009024-4008773 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT236842 NZ_LR740759:55560-55757 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References