Detailed information of TA system TA236838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3004958..3005663
• Replicon: chromosome
• Accession: NZ_CP092639
• Organism: Escherichia coli strain HS

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: MJ392_RS14585
• Protein ID: WP_000539521.1
• Coordinates: 3004958..3005344 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MJ392_RS14590
• Protein ID: WP_001280945.1
• Coordinates: 3005334..3005663 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ392_RS14565 (3000962)	3000962..3001588	+	627	WP_012135850.1	glutathione S-transferase GstB	-
MJ392_RS14570 (3001585)	3001585..3002700	-	1116	Protein_2868	aldose sugar dehydrogenase YliI	-
MJ392_RS14575 (3002811)	3002811..3003194	-	384	WP_000497137.1	biofilm formation regulator BssR	-
MJ392_RS14580 (3003407)	3003407..3004732	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
MJ392_RS14585 (3004958)	3004958..3005344	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MJ392_RS14590 (3005334)	3005334..3005663	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
MJ392_RS14595 (3005733)	3005733..3007061	-	1329	WP_000086877.1	GGDEF domain-containing protein	-
MJ392_RS14600 (3007069)	3007069..3009417	-	2349	WP_012135849.1	EAL domain-containing protein	-
MJ392_RS14605 (3009595)	3009595..3010506	-	912	WP_001236046.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T236838 WP_000539521.1 NZ_CP092639:3004958-3005344 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T236838 NZ_LR740758:4606974-4607360 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCCGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT236838 WP_001280945.1 NZ_CP092639:3005334-3005663 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT236838 NZ_LR740758:4606372-4606944 [Escherichia coli]
ATGTTTTGCGAAGAAAAAGTAGCTCAAATGGCTGCATACCTACTTCTTAAGCGAGGTGGGCGCATGGCATATCTGAAATT
GATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGAAGATAGCCTTTACTCTA
TGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGTATTGGTGACTACTGGTACAAC
CTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGACGAGGTCTTTGATGAGTT
GAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATTTGATCTCGCAAACATGA
CGCATTTAGAAAGCGTTTGTCCAGAGTGGCACAATCCTGGCAATTCTCGTAAGCCTATAGACCTGAAAGAAATGCTGATC
AGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAACTTAAGGAATTTTCTTT
GCAATTATCATGA

Structures

Toxin

• AlphaFold DB: A0A829GCT6