Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA(toxin) |
| Location | 1711573..1713356 | Replicon | chromosome |
| Accession | NZ_CP092635 | ||
| Organism | Enterobacter cloacae strain EFN743 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A7Z1F8U6 |
| Locus tag | MKZ88_RS08250 | Protein ID | WP_048972324.1 |
| Coordinates | 1712007..1713356 (-) | Length | 450 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | MKZ88_RS08245 | Protein ID | WP_029883072.1 |
| Coordinates | 1711573..1712010 (-) | Length | 146 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKZ88_RS08225 (MKZ88_08225) | 1706578..1707600 | + | 1023 | WP_045292101.1 | HTH-type transcriptional regulator GalS | - |
| MKZ88_RS08230 (MKZ88_08230) | 1707896..1708894 | + | 999 | WP_014832691.1 | galactose/glucose ABC transporter substrate-binding protein MglB | - |
| MKZ88_RS08235 (MKZ88_08235) | 1708975..1710495 | + | 1521 | WP_029883073.1 | galactose/methyl galactoside ABC transporter ATP-binding protein MglA | - |
| MKZ88_RS08240 (MKZ88_08240) | 1710511..1711521 | + | 1011 | WP_013097952.1 | galactose/methyl galactoside ABC transporter permease MglC | - |
| MKZ88_RS08245 (MKZ88_08245) | 1711573..1712010 | - | 438 | WP_029883072.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MKZ88_RS08250 (MKZ88_08250) | 1712007..1713356 | - | 1350 | WP_048972324.1 | HipA domain-containing protein | Toxin |
| MKZ88_RS08255 (MKZ88_08255) | 1713491..1714204 | - | 714 | WP_023619764.1 | outer membrane permeability protein SanA | - |
| MKZ88_RS08260 (MKZ88_08260) | 1714332..1715216 | - | 885 | WP_023619765.1 | cytidine deaminase | - |
| MKZ88_RS08265 (MKZ88_08265) | 1715346..1716041 | - | 696 | WP_013097948.1 | CidB/LrgB family autolysis modulator | - |
| MKZ88_RS08270 (MKZ88_08270) | 1716038..1716436 | - | 399 | WP_023619766.1 | CidA/LrgA family protein | - |
| MKZ88_RS08275 (MKZ88_08275) | 1716604..1717536 | + | 933 | WP_013097946.1 | tRNA dihydrouridine(16) synthase DusC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 450 a.a. Molecular weight: 51193.70 Da Isoelectric Point: 4.5003
>T236808 WP_048972324.1 NZ_CP092635:c1713356-1712007 [Enterobacter cloacae]
METLTVQAYLNETWTDIALIKYPGSENNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVDQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHDTAVQLIDLPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL
METLTVQAYLNETWTDIALIKYPGSENNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDQGQPGWLRFIDDII
PAGASRRYWINALDISELPVDQQNFLLLKFGTMSPVGNLRIKESVPEWNEFARTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVDTMR
LEEGSHYPSLWLPRFDIVRNEQDQLIRLGMESVYSLLQKAPGTLLDHEATLRALINKITSSHMVQQQGYQFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENHIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNAIAQALAEWIPPTT
LLDALHDTAVQLIDLPERLEARGVPDQIMEMPAIGFRYIPNKLSRWGLL
Download Length: 1350 bp
>T236808 NZ_LR739069:c5753394-5753116 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 146 a.a. Molecular weight: 16218.68 Da Isoelectric Point: 10.6347
>AT236808 WP_029883072.1 NZ_CP092635:c1712010-1711573 [Enterobacter cloacae]
MKISNKSESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSSGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT
MKISNKSESELLQTLARVRSVNEKRRHDEDEDPDKSSVVKRQRVSSGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGMKQDEYAKLVSVSRKTLSDVENGRGNYSADIINKIFKPFGLQTGLVPISKSLIASLFT
Download Length: 438 bp
>AT236808 NZ_LR739069:c5753104-5752799 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|