236807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1250190..1250860 Replicon chromosome
Accession NZ_CP092635
Organism Enterobacter cloacae strain EFN743

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag MKZ88_RS06050 Protein ID WP_096897066.1
Coordinates 1250190..1250519 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag MKZ88_RS06055 Protein ID WP_096897067.1
Coordinates 1250540..1250860 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKZ88_RS06035 (MKZ88_06035) 1245727..1247496 - 1770 WP_058651059.1 ATP-binding protein -
MKZ88_RS06040 (MKZ88_06040) 1247484..1248602 - 1119 WP_252614963.1 SIR2 family protein -
MKZ88_RS06045 (MKZ88_06045) 1248610..1249769 - 1160 Protein_1180 integrase domain-containing protein -
MKZ88_RS06050 (MKZ88_06050) 1250190..1250519 - 330 WP_096897066.1 TA system toxin CbtA family protein Toxin
MKZ88_RS06055 (MKZ88_06055) 1250540..1250860 - 321 WP_096897067.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MKZ88_RS06060 (MKZ88_06060) 1250878..1251099 - 222 WP_079819549.1 DUF987 domain-containing protein -
MKZ88_RS06065 (MKZ88_06065) 1251108..1251590 - 483 WP_096897068.1 DNA repair protein RadC -
MKZ88_RS06070 (MKZ88_06070) 1251599..1252048 - 450 WP_096897069.1 antirestriction protein -
MKZ88_RS06075 (MKZ88_06075) 1252148..1252387 - 240 WP_096897070.1 DUF905 domain-containing protein -
MKZ88_RS06080 (MKZ88_06080) 1252464..1252931 - 468 WP_096897071.1 protein YfjT -
MKZ88_RS06085 (MKZ88_06085) 1252955..1253395 - 441 WP_096897072.1 hypothetical protein -
MKZ88_RS06090 (MKZ88_06090) 1253395..1253631 - 237 WP_001144031.1 protein YpjK -
MKZ88_RS06095 (MKZ88_06095) 1253672..1254373 - 702 WP_001581462.1 WYL domain-containing protein -
MKZ88_RS06100 (MKZ88_06100) 1254590..1255411 - 822 WP_096897073.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1242813..1268598 25785


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(6-105)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12326.35 Da        Isoelectric Point: 8.9546

>T236807 WP_096897066.1 NZ_CP092635:c1250519-1250190 [Enterobacter cloacae]
MKTLPATISRAAKPCLTPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSTGLLKANVK

Download         Length: 330 bp

>T236807 NZ_LR739069:c4864471-4863716 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11791.42 Da        Isoelectric Point: 7.6922

>AT236807 WP_096897067.1 NZ_CP092635:c1250860-1250540 [Enterobacter cloacae]
MRSNATWGLRRDITPRLGACLVQEGNRLHYLAGRASITGKFSDAECLKLDAAFPHFISQMESMLTTGEMNSRHAHCAILY
HNGFTCEADTLGSCGYVYIAIYSTQR

Download         Length: 321 bp

>AT236807 NZ_LR739069:c4864974-4864606 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References